STRINGSTRING
Hspa1a protein (Cricetulus griseus) - STRING interaction network
"Hspa1a" - Heat shock 70 kDa protein 1A/1B in Cricetulus griseus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Hspa1aHeat shock 70 kDa protein 1A/1B; Derived by automated computational analysis using gene prediction method- Gnomon. Supporting evidence includes similarity to- 76 Proteins, and 100% coverage of the annotated genomic feature by RNAseq alignments; Belongs to the heat shock protein 70 family (641 aa)    
Predicted Functional Partners:
Dnajb1
DnaJ-like subfamily B member 1; The sequence of the model RefSeq protein was modified relative to its source genomic sequence to represent the inferred CDS- added 76 bases not found in genome assembly (340 aa)
 
  0.980
Hsp90ab1
Heat shock protein HSP 90-beta (724 aa)
     
 
  0.946
HSPCA
Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (733 aa)
     
 
  0.945
Hspa2
Heat shock-related 70 kDa protein 2; Derived by automated computational analysis using gene prediction method- Gnomon. Supporting evidence includes similarity to- 29 Proteins, and 100% coverage of the annotated genomic feature by RNAseq alignments; Belongs to the heat shock protein 70 family (634 aa)
   
 
0.919
Hspb1
Heat shock protein beta-1 isoform X2; Belongs to the small heat shock protein (HSP20) family (142 aa)
     
  0.906
Hspb2
Heat shock protein beta-2; Belongs to the small heat shock protein (HSP20) family (182 aa)
     
  0.906
Dnajc3
DnaJ-like subfamily C member 3; The sequence of the model RefSeq protein was modified relative to its source genomic sequence to represent the inferred CDS- added 111 bases not found in genome assembly (492 aa)
   
  0.900
Gak
cyclin-G-associated kinase isoform X5 (1220 aa)
       
 
  0.895
STIP1
Stress-induced-phosphoprotein 1; Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (543 aa)
     
 
  0.884
Tlr2
Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
       
  0.877
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus, Cricetulus griseus, Cricetus griseus
Server load: low (11%) [HD]