STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Bace1Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)    
Predicted Functional Partners:
Rtn4
Reticulon-4.
   
 0.972
I79_021368
Reticulon.
   
 0.963
App
Amyloid beta A4 protein.
    
 0.912
Gga1
ADP-ribosylation factor-binding protein GGA1.
    
 0.905
Psen1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
   
 
 0.904
Ncstn
Nicastrin.
    
 
 0.812
Adam10
Disintegrin and metalloproteinase domain-containing protein 10.
    
 
 0.776
Ide
Insulin-degrading enzyme; Belongs to the peptidase M16 family.
     
 0.762
Psen2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
   
 
 0.731
I79_012659
Reticulon.
   
 
 0.729
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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