STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PenkMet-enkephalin-Arg-Gly-Leu; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(238-259) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum. (268 aa)    
Predicted Functional Partners:
Oprm1
Mu-type opioid receptor; Belongs to the G-protein coupled receptor 1 family.
    
 0.998
Oprd1
Delta-type opioid receptor; Belongs to the G-protein coupled receptor 1 family.
    
 0.987
Oprl1
Nociceptin receptor isoform X1; Belongs to the G-protein coupled receptor 1 family.
    
 0.946
Pomc
Pro-opiomelanocortin.
     
 0.937
Oprk1
Kappa-type opioid receptor; Belongs to the G-protein coupled receptor 1 family.
    
 0.901
Pdyn
proenkephalin-B.
    
0.899
Pnoc
Prepronociceptin isoform X3.
     
 0.894
Npbwr1
Neuropeptides B/W receptor type 1; Belongs to the G-protein coupled receptor 1 family.
    
 0.862
Sst
Somatostatin.
  
  
 0.858
Npy
Pro-neuropeptide Y.
     
 0.762
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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