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UMN179_00174 protein (Gallibacterium anatis) - STRING interaction network
"UMN179_00174" - Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase in Gallibacterium anatis
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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UMN179_00174Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase (442 aa)    
Predicted Functional Partners:
UMN179_00309
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives (277 aa)
 
  0.999
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (420 aa)
 
  0.994
UMN179_01397
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (159 aa)
   
  0.991
UMN179_00668
2-amino-4-hydroxy-6- hydroxymethyldihyropteridine pyrophosphokinase (160 aa)
 
 
  0.913
folE
GTP cyclohydrolase I (218 aa)
 
  0.905
folD
5,10-methylene-tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (287 aa)
 
  0.897
UMN179_02312
Triphosphate 2’-epimerase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin (119 aa)
   
 
  0.894
argA
N-acetylglutamate synthase (442 aa)
     
 
    0.810
thyA
Thymidylate synthase; Provides the sole de novo source of dTMP for DNA biosynthesis (283 aa)
     
 
  0.803
UMN179_02469
Short chain dehydrogenase (240 aa)
   
    0.790
Your Current Organism:
Gallibacterium anatis
NCBI taxonomy Id: 1005058
Other names: G. anatis, G. anatis UMN179, Gallibacterium, Gallibacterium Christensen et al. 2003 emend. Bisgaard et al. 2009, Gallibacterium anatis, Gallibacterium anatis UMN179, Gallibacterium anatis str. UMN179, Gallibacterium anatis strain UMN179, Pasteurella anatis, Salpingitia sp. 10672/6, Salpingitia sp. 10672/9, Salpingitia sp. 12158, Salpingitia sp. 20558, Salpingitia sp. 36961/sv7, Salpingitia sp. BJ3453, Salpingitia sp. BK3387.2, Salpingitia sp. CCM 5995, Salpingitia sp. Gerl.220, Salpingitia sp. Gerl.3348/80, Salpingitia sp. Gerl.4224, Salpingitia sp. IPDH 697/78, avian Pasteurella haemolytica complex
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