Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
CRISPR-associated helicase Cas3 (1011 aa)
Predicted Functional Partners:
CRISPR-associated protein (333 aa)
CRISPR-associated protein (189 aa)
CRISPR-associated protein (434 aa)
CRISPR-associated protein (335 aa)
Cysteine/glutathione ABC transporter membrane/ATP-binding protein (580 aa)
Cysteine/glutathione ABC transporter membrane/ATP-binding protein (584 aa)
Thioredoxin reductase (320 aa)
CRISPR associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette (336 aa)