STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACTActin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (376 aa)    
Predicted Functional Partners:
HPODL_03468
Actin; Belongs to the actin family.
    
0.994
HPODL_02155
Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family.
    
 0.991
COF1
Cofilin; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with [...]
   
 0.990
HPODL_05179
Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.
    
 0.974
HPODL_01335
Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
 0.968
HPODL_02009
Actin-related protein 3; Belongs to the actin family.
  
0.968
HPODL_03580
Proline-rich protein LAS17.
    
 0.966
HPODL_01608
Tropomyosin.
   
 0.965
HPODL_04397
Protein BNI1.
    
 0.959
HPODL_03081
Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.
  
 
0.958
Your Current Organism:
Ogataea parapolymorpha
NCBI taxonomy Id: 871575
Other names: Hansenula polymorpha DL-1, O. parapolymorpha DL-1, Ogataea parapolymorpha ATCC 26012, Ogataea parapolymorpha DL-1, Pichia angusta DL-1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.