node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gli1 | Slfn4 | ENSMUSP00000026474 | ENSMUSP00000000208 | Zinc finger protein GLI1; Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling; Belongs to the GLI C2H2-type zinc-finger protein family. | Schlafen 4. | 0.545 |
Ifi44 | Ifit1 | ENSMUSP00000029671 | ENSMUSP00000099888 | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | Interferon-induced protein with tetratricopeptide repeats 1; Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP- RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'- triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non- [...] | 0.977 |
Ifi44 | Ms4a4c | ENSMUSP00000029671 | ENSMUSP00000072512 | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | Membrane-spanning 4-domains, subfamily A, member 4C. | 0.414 |
Ifi44 | Oas3 | ENSMUSP00000029671 | ENSMUSP00000035588 | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | 2'-5'-oligoadenylate synthase 3; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibi [...] | 0.871 |
Ifi44 | Oasl1 | ENSMUSP00000029671 | ENSMUSP00000107771 | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | 2'-5'-oligoadenylate synthase-like protein 1; Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity via an alternative antiviral pathway independent of RNase L; Belongs to the 2-5A synthase family. | 0.867 |
Ifi44 | Slfn4 | ENSMUSP00000029671 | ENSMUSP00000000208 | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | Schlafen 4. | 0.541 |
Ifi44 | Slfn8 | ENSMUSP00000029671 | ENSMUSP00000040060 | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | Schlafen family member 8; Endoribonuclease that cleaves tRNAs and rRNAs. Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem. May be involved in immune system via regulation of inflammation. | 0.587 |
Ifi44 | Zbp1 | ENSMUSP00000029671 | ENSMUSP00000029018 | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | Z-DNA-binding protein 1; Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3. | 0.673 |
Ifit1 | Ifi44 | ENSMUSP00000099888 | ENSMUSP00000029671 | Interferon-induced protein with tetratricopeptide repeats 1; Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP- RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'- triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non- [...] | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | 0.977 |
Ifit1 | Oas3 | ENSMUSP00000099888 | ENSMUSP00000035588 | Interferon-induced protein with tetratricopeptide repeats 1; Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP- RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'- triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non- [...] | 2'-5'-oligoadenylate synthase 3; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibi [...] | 0.930 |
Ifit1 | Oasl1 | ENSMUSP00000099888 | ENSMUSP00000107771 | Interferon-induced protein with tetratricopeptide repeats 1; Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP- RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'- triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non- [...] | 2'-5'-oligoadenylate synthase-like protein 1; Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity via an alternative antiviral pathway independent of RNase L; Belongs to the 2-5A synthase family. | 0.879 |
Ifit1 | Slfn4 | ENSMUSP00000099888 | ENSMUSP00000000208 | Interferon-induced protein with tetratricopeptide repeats 1; Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP- RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'- triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non- [...] | Schlafen 4. | 0.450 |
Ifit1 | Slfn8 | ENSMUSP00000099888 | ENSMUSP00000040060 | Interferon-induced protein with tetratricopeptide repeats 1; Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP- RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'- triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non- [...] | Schlafen family member 8; Endoribonuclease that cleaves tRNAs and rRNAs. Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem. May be involved in immune system via regulation of inflammation. | 0.572 |
Ifit1 | Zbp1 | ENSMUSP00000099888 | ENSMUSP00000029018 | Interferon-induced protein with tetratricopeptide repeats 1; Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP- RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'- triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non- [...] | Z-DNA-binding protein 1; Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3. | 0.699 |
Ms4a4c | Ifi44 | ENSMUSP00000072512 | ENSMUSP00000029671 | Membrane-spanning 4-domains, subfamily A, member 4C. | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | 0.414 |
Ms4a4c | Oasl1 | ENSMUSP00000072512 | ENSMUSP00000107771 | Membrane-spanning 4-domains, subfamily A, member 4C. | 2'-5'-oligoadenylate synthase-like protein 1; Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity via an alternative antiviral pathway independent of RNase L; Belongs to the 2-5A synthase family. | 0.400 |
Ms4a4c | Slfn4 | ENSMUSP00000072512 | ENSMUSP00000000208 | Membrane-spanning 4-domains, subfamily A, member 4C. | Schlafen 4. | 0.498 |
Ms4a4c | Slfn8 | ENSMUSP00000072512 | ENSMUSP00000040060 | Membrane-spanning 4-domains, subfamily A, member 4C. | Schlafen family member 8; Endoribonuclease that cleaves tRNAs and rRNAs. Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem. May be involved in immune system via regulation of inflammation. | 0.484 |
Ms4a4c | Zbp1 | ENSMUSP00000072512 | ENSMUSP00000029018 | Membrane-spanning 4-domains, subfamily A, member 4C. | Z-DNA-binding protein 1; Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3. | 0.400 |
Oas3 | Ifi44 | ENSMUSP00000035588 | ENSMUSP00000029671 | 2'-5'-oligoadenylate synthase 3; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibi [...] | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | 0.871 |