node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Slc13a2 | Slc25a1 | ENSMUSP00000001122 | ENSMUSP00000003622 | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate. | Tricarboxylate transport protein, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation. Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.485 |
Slc13a2 | Slc26a2 | ENSMUSP00000001122 | ENSMUSP00000119447 | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate. | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation. | 0.642 |
Slc13a2 | Slc26a4 | ENSMUSP00000001122 | ENSMUSP00000001253 | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate. | Pendrin; Sodium-independent transporter of chloride and iodide. | 0.543 |
Slc13a2 | Slc26a6 | ENSMUSP00000001122 | ENSMUSP00000095979 | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate. | Solute carrier family 26 member 6; Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS- sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Functions in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate- sulfate and chloride- [...] | 0.546 |
Slc13a2 | Slc36a2 | ENSMUSP00000001122 | ENSMUSP00000045613 | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate. | Proton-coupled amino acid transporter 2; Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids amino acids such as glycine, alanine and proline. Inhibited by sarcosine. | 0.516 |
Slc13a2 | Slc46a2 | ENSMUSP00000001122 | ENSMUSP00000030081 | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate. | Thymic stromal cotransporter protein; May act as a transporter. | 0.485 |
Slc13a2 | Slc5a1 | ENSMUSP00000001122 | ENSMUSP00000011178 | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate. | Sodium/glucose cotransporter 1; Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. | 0.529 |
Slc13a2 | Slc5a8 | ENSMUSP00000001122 | ENSMUSP00000020255 | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate. | Sodium-coupled monocarboxylate transporter 1; Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)- dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D- lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5- aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. M [...] | 0.552 |
Slc13a2 | Slc9a3 | ENSMUSP00000001122 | ENSMUSP00000038142 | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate. | Sodium/hydrogen exchanger 3; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.488 |
Slc13a2 | Tmem50a | ENSMUSP00000001122 | ENSMUSP00000030626 | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate. | Transmembrane protein 50A. | 0.520 |
Slc25a1 | Slc13a2 | ENSMUSP00000003622 | ENSMUSP00000001122 | Tricarboxylate transport protein, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation. Belongs to the mitochondrial carrier (TC 2.A.29) family. | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate. | 0.485 |
Slc26a2 | Slc13a2 | ENSMUSP00000119447 | ENSMUSP00000001122 | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation. | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate. | 0.642 |
Slc26a4 | Slc13a2 | ENSMUSP00000001253 | ENSMUSP00000001122 | Pendrin; Sodium-independent transporter of chloride and iodide. | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate. | 0.543 |
Slc26a4 | Slc5a8 | ENSMUSP00000001253 | ENSMUSP00000020255 | Pendrin; Sodium-independent transporter of chloride and iodide. | Sodium-coupled monocarboxylate transporter 1; Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)- dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D- lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5- aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. M [...] | 0.514 |
Slc26a4 | Slc9a3 | ENSMUSP00000001253 | ENSMUSP00000038142 | Pendrin; Sodium-independent transporter of chloride and iodide. | Sodium/hydrogen exchanger 3; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.621 |
Slc26a6 | Slc13a2 | ENSMUSP00000095979 | ENSMUSP00000001122 | Solute carrier family 26 member 6; Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS- sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Functions in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate- sulfate and chloride- [...] | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate. | 0.546 |
Slc26a6 | Slc9a3 | ENSMUSP00000095979 | ENSMUSP00000038142 | Solute carrier family 26 member 6; Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS- sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Functions in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate- sulfate and chloride- [...] | Sodium/hydrogen exchanger 3; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.785 |
Slc36a2 | Slc13a2 | ENSMUSP00000045613 | ENSMUSP00000001122 | Proton-coupled amino acid transporter 2; Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids amino acids such as glycine, alanine and proline. Inhibited by sarcosine. | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate. | 0.516 |
Slc46a2 | Slc13a2 | ENSMUSP00000030081 | ENSMUSP00000001122 | Thymic stromal cotransporter protein; May act as a transporter. | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate. | 0.485 |
Slc5a1 | Slc13a2 | ENSMUSP00000011178 | ENSMUSP00000001122 | Sodium/glucose cotransporter 1; Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate. | 0.529 |