node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Apob | Cideb | ENSMUSP00000036044 | ENSMUSP00000001497 | Apolipoprotein B-100; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | Cell death activator CIDE-B; Activates apoptosis. | 0.884 |
Apob | Hnf4a | ENSMUSP00000036044 | ENSMUSP00000018094 | Apolipoprotein B-100; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | Hepatocyte nuclear factor 4-alpha; Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitatating the recruitment of RNA pol II to the promoters of target genes (By similarity). Activates the transcription of CYP2C38. Represses the CLOCK-ARNTL/BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells ; Belongs to the nuclear hormone receptor family. NR2 subfamily. | 0.746 |
Apob | Mttp | ENSMUSP00000036044 | ENSMUSP00000096179 | Apolipoprotein B-100; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | Microsomal triglyceride transfer protein large subunit; Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins. Loads phospholipid into the C1D1 antigen-binding groove. Isoform 2 is critical for the development of natural killer T (NKT) cells. May have a role in the biogenesis of lipid droplets. | 0.999 |
Apob | Plin1 | ENSMUSP00000036044 | ENSMUSP00000146028 | Apolipoprotein B-100; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | Perilipin-1; Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness (By similarity). Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. | 0.409 |
Apob | Plin2 | ENSMUSP00000036044 | ENSMUSP00000000466 | Apolipoprotein B-100; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | Perilipin-2; May be involved in development and maintenance of adipose tissue. | 0.547 |
Apob | Plin3 | ENSMUSP00000036044 | ENSMUSP00000019726 | Apolipoprotein B-100; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | Perilipin-3; Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network; Belongs to the perilipin family. | 0.426 |
Cideb | Apob | ENSMUSP00000001497 | ENSMUSP00000036044 | Cell death activator CIDE-B; Activates apoptosis. | Apolipoprotein B-100; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | 0.884 |
Cideb | Dffa | ENSMUSP00000001497 | ENSMUSP00000030816 | Cell death activator CIDE-B; Activates apoptosis. | DNA fragmentation factor subunit alpha; Inhibitor of the caspase-activated DNase (DFF40). | 0.633 |
Cideb | Dffb | ENSMUSP00000001497 | ENSMUSP00000030893 | Cell death activator CIDE-B; Activates apoptosis. | DNA fragmentation factor subunit beta; Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. | 0.652 |
Cideb | Hnf4a | ENSMUSP00000001497 | ENSMUSP00000018094 | Cell death activator CIDE-B; Activates apoptosis. | Hepatocyte nuclear factor 4-alpha; Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitatating the recruitment of RNA pol II to the promoters of target genes (By similarity). Activates the transcription of CYP2C38. Represses the CLOCK-ARNTL/BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells ; Belongs to the nuclear hormone receptor family. NR2 subfamily. | 0.532 |
Cideb | Lpcat3 | ENSMUSP00000001497 | ENSMUSP00000004381 | Cell death activator CIDE-B; Activates apoptosis. | Lysophospholipid acyltransferase 5; Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). To a lesser extent, also catalyzes the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3- phosphoethanolamine or PE) (LPEAT activity), and the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidyl [...] | 0.574 |
Cideb | Mttp | ENSMUSP00000001497 | ENSMUSP00000096179 | Cell death activator CIDE-B; Activates apoptosis. | Microsomal triglyceride transfer protein large subunit; Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins. Loads phospholipid into the C1D1 antigen-binding groove. Isoform 2 is critical for the development of natural killer T (NKT) cells. May have a role in the biogenesis of lipid droplets. | 0.623 |
Cideb | Plin1 | ENSMUSP00000001497 | ENSMUSP00000146028 | Cell death activator CIDE-B; Activates apoptosis. | Perilipin-1; Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness (By similarity). Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. | 0.548 |
Cideb | Plin2 | ENSMUSP00000001497 | ENSMUSP00000000466 | Cell death activator CIDE-B; Activates apoptosis. | Perilipin-2; May be involved in development and maintenance of adipose tissue. | 0.624 |
Cideb | Plin3 | ENSMUSP00000001497 | ENSMUSP00000019726 | Cell death activator CIDE-B; Activates apoptosis. | Perilipin-3; Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network; Belongs to the perilipin family. | 0.579 |
Cideb | Plin5 | ENSMUSP00000001497 | ENSMUSP00000019808 | Cell death activator CIDE-B; Activates apoptosis. | Perilipin-5; Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hyd [...] | 0.632 |
Dffa | Cideb | ENSMUSP00000030816 | ENSMUSP00000001497 | DNA fragmentation factor subunit alpha; Inhibitor of the caspase-activated DNase (DFF40). | Cell death activator CIDE-B; Activates apoptosis. | 0.633 |
Dffa | Dffb | ENSMUSP00000030816 | ENSMUSP00000030893 | DNA fragmentation factor subunit alpha; Inhibitor of the caspase-activated DNase (DFF40). | DNA fragmentation factor subunit beta; Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. | 0.999 |
Dffa | Plin1 | ENSMUSP00000030816 | ENSMUSP00000146028 | DNA fragmentation factor subunit alpha; Inhibitor of the caspase-activated DNase (DFF40). | Perilipin-1; Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness (By similarity). Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. | 0.416 |
Dffb | Cideb | ENSMUSP00000030893 | ENSMUSP00000001497 | DNA fragmentation factor subunit beta; Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. | Cell death activator CIDE-B; Activates apoptosis. | 0.652 |