node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dhx34 | Etf1 | ENSMUSP00000092410 | ENSMUSP00000025218 | Probable ATP-dependent RNA helicase DHX34; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily. | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (By similarity). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). Belongs to the eukaryotic release factor 1 family. | 0.515 |
Dhx34 | Smg1 | ENSMUSP00000092410 | ENSMUSP00000032891 | Probable ATP-dependent RNA helicase DHX34; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily. | Serine/threonine-protein kinase SMG1; Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense- mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction compl [...] | 0.817 |
Dhx34 | Smg5 | ENSMUSP00000092410 | ENSMUSP00000001451 | Probable ATP-dependent RNA helicase DHX34; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily. | Protein SMG5; Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity (By similarity). | 0.726 |
Dhx34 | Smg6 | ENSMUSP00000092410 | ENSMUSP00000043555 | Probable ATP-dependent RNA helicase DHX34; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily. | Telomerase-binding protein EST1A; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER). | 0.714 |
Dhx34 | Smg7 | ENSMUSP00000092410 | ENSMUSP00000041241 | Probable ATP-dependent RNA helicase DHX34; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily. | Protein SMG7; Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (By similarity). | 0.682 |
Dhx34 | Smg8 | ENSMUSP00000092410 | ENSMUSP00000020801 | Probable ATP-dependent RNA helicase DHX34; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily. | Protein SMG8; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity (By similarity). | 0.865 |
Dhx34 | Smg9 | ENSMUSP00000092410 | ENSMUSP00000002280 | Probable ATP-dependent RNA helicase DHX34; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily. | Protein SMG9; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (By similarity). Plays a role in brain, heart, and eye development. | 0.879 |
Dhx34 | Upf1 | ENSMUSP00000092410 | ENSMUSP00000075089 | Probable ATP-dependent RNA helicase DHX34; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily. | Regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more n [...] | 0.795 |
Dhx34 | Upf2 | ENSMUSP00000092410 | ENSMUSP00000058375 | Probable ATP-dependent RNA helicase DHX34; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily. | Regulator of nonsense transcripts 2; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA. | 0.812 |
Dhx34 | Upf3a | ENSMUSP00000092410 | ENSMUSP00000037354 | Probable ATP-dependent RNA helicase DHX34; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily. | UPF3 regulator of nonsense transcripts homolog A (Yeast). | 0.823 |
Etf1 | Dhx34 | ENSMUSP00000025218 | ENSMUSP00000092410 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (By similarity). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). Belongs to the eukaryotic release factor 1 family. | Probable ATP-dependent RNA helicase DHX34; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily. | 0.515 |
Etf1 | Smg1 | ENSMUSP00000025218 | ENSMUSP00000032891 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (By similarity). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). Belongs to the eukaryotic release factor 1 family. | Serine/threonine-protein kinase SMG1; Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense- mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction compl [...] | 0.988 |
Etf1 | Smg5 | ENSMUSP00000025218 | ENSMUSP00000001451 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (By similarity). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). Belongs to the eukaryotic release factor 1 family. | Protein SMG5; Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity (By similarity). | 0.624 |
Etf1 | Smg6 | ENSMUSP00000025218 | ENSMUSP00000043555 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (By similarity). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). Belongs to the eukaryotic release factor 1 family. | Telomerase-binding protein EST1A; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER). | 0.612 |
Etf1 | Smg7 | ENSMUSP00000025218 | ENSMUSP00000041241 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (By similarity). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). Belongs to the eukaryotic release factor 1 family. | Protein SMG7; Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (By similarity). | 0.584 |
Etf1 | Smg8 | ENSMUSP00000025218 | ENSMUSP00000020801 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (By similarity). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). Belongs to the eukaryotic release factor 1 family. | Protein SMG8; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity (By similarity). | 0.850 |
Etf1 | Smg9 | ENSMUSP00000025218 | ENSMUSP00000002280 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (By similarity). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). Belongs to the eukaryotic release factor 1 family. | Protein SMG9; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (By similarity). Plays a role in brain, heart, and eye development. | 0.860 |
Etf1 | Upf1 | ENSMUSP00000025218 | ENSMUSP00000075089 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (By similarity). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). Belongs to the eukaryotic release factor 1 family. | Regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more n [...] | 0.834 |
Etf1 | Upf2 | ENSMUSP00000025218 | ENSMUSP00000058375 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (By similarity). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). Belongs to the eukaryotic release factor 1 family. | Regulator of nonsense transcripts 2; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA. | 0.805 |
Etf1 | Upf3a | ENSMUSP00000025218 | ENSMUSP00000037354 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (By similarity). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). Belongs to the eukaryotic release factor 1 family. | UPF3 regulator of nonsense transcripts homolog A (Yeast). | 0.698 |