node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Brox | Mdp1 | ENSMUSP00000061345 | ENSMUSP00000002400 | BRO1 domain-containing protein BROX. | Magnesium-dependent phosphatase 1; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. | 0.542 |
Clrn3 | Itprip | ENSMUSP00000056245 | ENSMUSP00000093697 | Clarin-3. | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release. Belongs to the ITPRIP family. | 0.404 |
Clrn3 | Mdp1 | ENSMUSP00000056245 | ENSMUSP00000002400 | Clarin-3. | Magnesium-dependent phosphatase 1; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. | 0.552 |
Itprip | Clrn3 | ENSMUSP00000093697 | ENSMUSP00000056245 | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release. Belongs to the ITPRIP family. | Clarin-3. | 0.404 |
Itprip | Mdp1 | ENSMUSP00000093697 | ENSMUSP00000002400 | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release. Belongs to the ITPRIP family. | Magnesium-dependent phosphatase 1; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. | 0.521 |
Mdp1 | Brox | ENSMUSP00000002400 | ENSMUSP00000061345 | Magnesium-dependent phosphatase 1; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. | BRO1 domain-containing protein BROX. | 0.542 |
Mdp1 | Clrn3 | ENSMUSP00000002400 | ENSMUSP00000056245 | Magnesium-dependent phosphatase 1; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. | Clarin-3. | 0.552 |
Mdp1 | Itprip | ENSMUSP00000002400 | ENSMUSP00000093697 | Magnesium-dependent phosphatase 1; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release. Belongs to the ITPRIP family. | 0.521 |
Mdp1 | Pdcd6ip | ENSMUSP00000002400 | ENSMUSP00000107492 | Magnesium-dependent phosphatase 1; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. | Programmed cell death 6-interacting protein; Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires [...] | 0.844 |
Mdp1 | Ptpn23 | ENSMUSP00000002400 | ENSMUSP00000039580 | Magnesium-dependent phosphatase 1; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. | Tyrosine-protein phosphatase non-receptor type 23; Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis (By similarity); Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | 0.850 |
Mdp1 | Rep15 | ENSMUSP00000002400 | ENSMUSP00000037503 | Magnesium-dependent phosphatase 1; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. | Rab15 effector protein; Regulates transferrin receptor recycling from the endocytic recycling compartment. | 0.489 |
Mdp1 | Rhpn1 | ENSMUSP00000002400 | ENSMUSP00000113042 | Magnesium-dependent phosphatase 1; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. | Rhophilin-1; Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules; Belongs to the RHPN family. | 0.536 |
Mdp1 | Rhpn2 | ENSMUSP00000002400 | ENSMUSP00000032705 | Magnesium-dependent phosphatase 1; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. | Rhophilin-2; Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (By similarity). | 0.536 |
Mdp1 | Slc5a5 | ENSMUSP00000002400 | ENSMUSP00000000809 | Magnesium-dependent phosphatase 1; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. | Sodium/iodide cotransporter; Mediates iodide uptake in the thyroid gland; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.476 |
Mdp1 | Slc5a8 | ENSMUSP00000002400 | ENSMUSP00000020255 | Magnesium-dependent phosphatase 1; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. | Sodium-coupled monocarboxylate transporter 1; Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)- dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D- lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5- aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. M [...] | 0.580 |
Pdcd6ip | Mdp1 | ENSMUSP00000107492 | ENSMUSP00000002400 | Programmed cell death 6-interacting protein; Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires [...] | Magnesium-dependent phosphatase 1; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. | 0.844 |
Ptpn23 | Mdp1 | ENSMUSP00000039580 | ENSMUSP00000002400 | Tyrosine-protein phosphatase non-receptor type 23; Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis (By similarity); Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | Magnesium-dependent phosphatase 1; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. | 0.850 |
Rep15 | Mdp1 | ENSMUSP00000037503 | ENSMUSP00000002400 | Rab15 effector protein; Regulates transferrin receptor recycling from the endocytic recycling compartment. | Magnesium-dependent phosphatase 1; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. | 0.489 |
Rhpn1 | Mdp1 | ENSMUSP00000113042 | ENSMUSP00000002400 | Rhophilin-1; Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules; Belongs to the RHPN family. | Magnesium-dependent phosphatase 1; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. | 0.536 |
Rhpn2 | Mdp1 | ENSMUSP00000032705 | ENSMUSP00000002400 | Rhophilin-2; Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (By similarity). | Magnesium-dependent phosphatase 1; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. | 0.536 |