node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Apobec3 | Foxj2 | ENSMUSP00000105249 | ENSMUSP00000003238 | DNA dC->dU-editing enzyme APOBEC-3; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent mechanisms. Selectively targets single- stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against HIV-1, simian immunodeficiency viruses (SIVs), mouse mammary tumor virus (MMTV) and friend murine leukemia virus (FrMLV) and may inhibit the mobility of LTR retrotransposons. | Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. | 0.496 |
Foxj2 | Apobec3 | ENSMUSP00000003238 | ENSMUSP00000105249 | Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. | DNA dC->dU-editing enzyme APOBEC-3; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent mechanisms. Selectively targets single- stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against HIV-1, simian immunodeficiency viruses (SIVs), mouse mammary tumor virus (MMTV) and friend murine leukemia virus (FrMLV) and may inhibit the mobility of LTR retrotransposons. | 0.496 |
Foxj2 | Foxl1 | ENSMUSP00000003238 | ENSMUSP00000137732 | Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. | Forkhead box protein L1; Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors. | 0.462 |
Foxj2 | Nf1 | ENSMUSP00000003238 | ENSMUSP00000071289 | Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. | Neurofibromin; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. | 0.578 |
Foxj2 | Pax2 | ENSMUSP00000003238 | ENSMUSP00000134661 | Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. | Paired box protein Pax-2; Transcription factor that may have a role in kidney cell differentiation. | 0.574 |
Foxj2 | Pax4 | ENSMUSP00000003238 | ENSMUSP00000031718 | Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. | Paired box protein Pax-4; Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that competes with PAX6 in binding to a common element in the glucagon, insulin and somatostatin promoters; Belongs to the paired homeobox family. | 0.480 |
Foxj2 | Pax6 | ENSMUSP00000003238 | ENSMUSP00000087870 | Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. | Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). | 0.618 |
Foxj2 | Pou3f2 | ENSMUSP00000003238 | ENSMUSP00000136147 | Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. | POU domain, class 3, transcription factor 2; Transcription factor that plays a key role in neuronal differentiation. Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes [...] | 0.713 |
Foxj2 | Rfx1 | ENSMUSP00000003238 | ENSMUSP00000005600 | Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. | MHC class II regulatory factor RFX1; Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes (By similarity). | 0.708 |
Foxj2 | Srebf2 | ENSMUSP00000003238 | ENSMUSP00000023100 | Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. | Processed sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. | 0.477 |
Foxj2 | Zscan2 | ENSMUSP00000003238 | ENSMUSP00000042321 | Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. | Zinc finger and SCAN domain-containing protein 2; May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis. | 0.499 |
Foxl1 | Foxj2 | ENSMUSP00000137732 | ENSMUSP00000003238 | Forkhead box protein L1; Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors. | Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. | 0.462 |
Nf1 | Foxj2 | ENSMUSP00000071289 | ENSMUSP00000003238 | Neurofibromin; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. | Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. | 0.578 |
Nf1 | Pax4 | ENSMUSP00000071289 | ENSMUSP00000031718 | Neurofibromin; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. | Paired box protein Pax-4; Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that competes with PAX6 in binding to a common element in the glucagon, insulin and somatostatin promoters; Belongs to the paired homeobox family. | 0.449 |
Nf1 | Pax6 | ENSMUSP00000071289 | ENSMUSP00000087870 | Neurofibromin; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. | Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). | 0.630 |
Nf1 | Rfx1 | ENSMUSP00000071289 | ENSMUSP00000005600 | Neurofibromin; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. | MHC class II regulatory factor RFX1; Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes (By similarity). | 0.590 |
Pax2 | Foxj2 | ENSMUSP00000134661 | ENSMUSP00000003238 | Paired box protein Pax-2; Transcription factor that may have a role in kidney cell differentiation. | Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. | 0.574 |
Pax2 | Pax6 | ENSMUSP00000134661 | ENSMUSP00000087870 | Paired box protein Pax-2; Transcription factor that may have a role in kidney cell differentiation. | Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). | 0.500 |
Pax4 | Foxj2 | ENSMUSP00000031718 | ENSMUSP00000003238 | Paired box protein Pax-4; Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that competes with PAX6 in binding to a common element in the glucagon, insulin and somatostatin promoters; Belongs to the paired homeobox family. | Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. | 0.480 |
Pax4 | Nf1 | ENSMUSP00000031718 | ENSMUSP00000071289 | Paired box protein Pax-4; Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that competes with PAX6 in binding to a common element in the glucagon, insulin and somatostatin promoters; Belongs to the paired homeobox family. | Neurofibromin; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. | 0.449 |