node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ephx1 | Gstk1 | ENSMUSP00000047551 | ENSMUSP00000031897 | Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Belongs to the peptidase S33 family. | Glutathione S-transferase kappa 1; Belongs to the GST superfamily. Kappa family. | 0.746 |
Ephx1 | Gstm5 | ENSMUSP00000047551 | ENSMUSP00000004134 | Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Belongs to the peptidase S33 family. | Glutathione S-transferase Mu 5; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family. | 0.822 |
Ephx1 | Gsto1 | ENSMUSP00000047551 | ENSMUSP00000026050 | Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Belongs to the peptidase S33 family. | Glutathione S-transferase omega-1; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. Belongs to the GST superfamily. Omega family. | 0.799 |
Ephx1 | Gsto2 | ENSMUSP00000047551 | ENSMUSP00000052592 | Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Belongs to the peptidase S33 family. | Glutathione S-transferase omega-2; Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). Belongs to the GST superfamily. Omega family. | 0.720 |
Ephx1 | Gstt1 | ENSMUSP00000047551 | ENSMUSP00000001713 | Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Belongs to the peptidase S33 family. | Glutathione S-transferase theta-1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity. | 0.843 |
Ephx1 | Gstt2 | ENSMUSP00000047551 | ENSMUSP00000151239 | Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Belongs to the peptidase S33 family. | Glutathione S-transferase theta-2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. | 0.758 |
Ephx1 | Gstt3 | ENSMUSP00000047551 | ENSMUSP00000001715 | Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Belongs to the peptidase S33 family. | Glutathione S-transferase theta-3; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Shows high activity towards 4-nitrobenzyl chloride (4-NBC). Also has lower activity towards 1,2-epoxy-3-(p-nitrophenoxy)propane (EPNP), cumene hydroperoxide, 1- chloro-2,4-dinitrobenzene (CDNB), 7-chloro-4-nitrobenzo-2-oxa-1,3- diazole (NBD-Cl), and ethacrynic acid. | 0.720 |
Gstk1 | Ephx1 | ENSMUSP00000031897 | ENSMUSP00000047551 | Glutathione S-transferase kappa 1; Belongs to the GST superfamily. Kappa family. | Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Belongs to the peptidase S33 family. | 0.746 |
Gstk1 | Gstm5 | ENSMUSP00000031897 | ENSMUSP00000004134 | Glutathione S-transferase kappa 1; Belongs to the GST superfamily. Kappa family. | Glutathione S-transferase Mu 5; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family. | 0.820 |
Gstk1 | Gsto1 | ENSMUSP00000031897 | ENSMUSP00000026050 | Glutathione S-transferase kappa 1; Belongs to the GST superfamily. Kappa family. | Glutathione S-transferase omega-1; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. Belongs to the GST superfamily. Omega family. | 0.877 |
Gstk1 | Gsto2 | ENSMUSP00000031897 | ENSMUSP00000052592 | Glutathione S-transferase kappa 1; Belongs to the GST superfamily. Kappa family. | Glutathione S-transferase omega-2; Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). Belongs to the GST superfamily. Omega family. | 0.902 |
Gstk1 | Gstt1 | ENSMUSP00000031897 | ENSMUSP00000001713 | Glutathione S-transferase kappa 1; Belongs to the GST superfamily. Kappa family. | Glutathione S-transferase theta-1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity. | 0.921 |
Gstk1 | Gstt2 | ENSMUSP00000031897 | ENSMUSP00000151239 | Glutathione S-transferase kappa 1; Belongs to the GST superfamily. Kappa family. | Glutathione S-transferase theta-2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. | 0.908 |
Gstk1 | Gstt3 | ENSMUSP00000031897 | ENSMUSP00000001715 | Glutathione S-transferase kappa 1; Belongs to the GST superfamily. Kappa family. | Glutathione S-transferase theta-3; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Shows high activity towards 4-nitrobenzyl chloride (4-NBC). Also has lower activity towards 1,2-epoxy-3-(p-nitrophenoxy)propane (EPNP), cumene hydroperoxide, 1- chloro-2,4-dinitrobenzene (CDNB), 7-chloro-4-nitrobenzo-2-oxa-1,3- diazole (NBD-Cl), and ethacrynic acid. | 0.817 |
Gstk1 | Gstz1 | ENSMUSP00000031897 | ENSMUSP00000053540 | Glutathione S-transferase kappa 1; Belongs to the GST superfamily. Kappa family. | Maleylacetoacetate isomerase; Probable bifunctional enzyme showing minimal glutathione- conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2- oxa-1, 3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with t-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid (By similarity). Belongs to the GST superfamily. Zeta family. | 0.673 |
Gstk1 | Prdx6 | ENSMUSP00000031897 | ENSMUSP00000071636 | Glutathione S-transferase kappa 1; Belongs to the GST superfamily. Kappa family. | Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] | 0.748 |
Gstk1 | Prdx6b | ENSMUSP00000031897 | ENSMUSP00000133276 | Glutathione S-transferase kappa 1; Belongs to the GST superfamily. Kappa family. | Peroxiredoxin 6, related sequence 1. | 0.701 |
Gstm5 | Ephx1 | ENSMUSP00000004134 | ENSMUSP00000047551 | Glutathione S-transferase Mu 5; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family. | Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Belongs to the peptidase S33 family. | 0.822 |
Gstm5 | Gstk1 | ENSMUSP00000004134 | ENSMUSP00000031897 | Glutathione S-transferase Mu 5; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family. | Glutathione S-transferase kappa 1; Belongs to the GST superfamily. Kappa family. | 0.820 |
Gstm5 | Gsto1 | ENSMUSP00000004134 | ENSMUSP00000026050 | Glutathione S-transferase Mu 5; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family. | Glutathione S-transferase omega-1; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. Belongs to the GST superfamily. Omega family. | 0.890 |