node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Clvs1 | Mospd2 | ENSMUSP00000035649 | ENSMUSP00000004715 | Clavesin-1; Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). | Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines. | 0.594 |
Leap2 | Mospd2 | ENSMUSP00000044166 | ENSMUSP00000004715 | Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity; Belongs to the LEAP2 family. | Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines. | 0.599 |
Mospd1 | Mospd2 | ENSMUSP00000023836 | ENSMUSP00000004715 | Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation. | Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines. | 0.741 |
Mospd1 | Osbp | ENSMUSP00000023836 | ENSMUSP00000025590 | Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation. | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25- hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol [...] | 0.563 |
Mospd1 | Stard3 | ENSMUSP00000023836 | ENSMUSP00000018311 | Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation. | StAR-related lipid transfer protein 3; Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (By similarity). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (By similarity). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (By similarity). May also mediate cholesterol transport between other membra [...] | 0.487 |
Mospd1 | Stard3nl | ENSMUSP00000023836 | ENSMUSP00000142680 | Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation. | STARD3 N-terminal-like protein; Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB. | 0.537 |
Mospd2 | Clvs1 | ENSMUSP00000004715 | ENSMUSP00000035649 | Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines. | Clavesin-1; Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). | 0.594 |
Mospd2 | Leap2 | ENSMUSP00000004715 | ENSMUSP00000044166 | Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines. | Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity; Belongs to the LEAP2 family. | 0.599 |
Mospd2 | Mospd1 | ENSMUSP00000004715 | ENSMUSP00000023836 | Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines. | Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation. | 0.741 |
Mospd2 | Mospd3 | ENSMUSP00000004715 | ENSMUSP00000040828 | Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines. | Motile sperm domain-containing protein 3. | 0.688 |
Mospd2 | Osbp | ENSMUSP00000004715 | ENSMUSP00000025590 | Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines. | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25- hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol [...] | 0.603 |
Mospd2 | Osbpl1a | ENSMUSP00000004715 | ENSMUSP00000073957 | Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines. | Oxysterol-binding protein-related protein 1; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol. | 0.955 |
Mospd2 | Osbpl2 | ENSMUSP00000004715 | ENSMUSP00000046538 | Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines. | Oxysterol-binding protein-related protein 2; Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane. Binds phosphoinositides, such as phosphatidylinositol-4,5- bisphosphate. Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro); Belongs to the [...] | 0.624 |
Mospd2 | Rmdn3 | ENSMUSP00000004715 | ENSMUSP00000092283 | Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines. | Regulator of microtubule dynamics protein 3; Involved in cellular calcium homeostasis regulation (By similarity). May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis (By similarity). Belongs to the RMDN family. | 0.631 |
Mospd2 | Stard3 | ENSMUSP00000004715 | ENSMUSP00000018311 | Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines. | StAR-related lipid transfer protein 3; Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (By similarity). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (By similarity). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (By similarity). May also mediate cholesterol transport between other membra [...] | 0.912 |
Mospd2 | Stard3nl | ENSMUSP00000004715 | ENSMUSP00000142680 | Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines. | STARD3 N-terminal-like protein; Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB. | 0.664 |
Mospd3 | Mospd2 | ENSMUSP00000040828 | ENSMUSP00000004715 | Motile sperm domain-containing protein 3. | Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines. | 0.688 |
Mospd3 | Osbp | ENSMUSP00000040828 | ENSMUSP00000025590 | Motile sperm domain-containing protein 3. | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25- hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol [...] | 0.571 |
Mospd3 | Stard3 | ENSMUSP00000040828 | ENSMUSP00000018311 | Motile sperm domain-containing protein 3. | StAR-related lipid transfer protein 3; Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (By similarity). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (By similarity). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (By similarity). May also mediate cholesterol transport between other membra [...] | 0.538 |
Mospd3 | Stard3nl | ENSMUSP00000040828 | ENSMUSP00000142680 | Motile sperm domain-containing protein 3. | STARD3 N-terminal-like protein; Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB. | 0.565 |