node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aldob | Cyp2d26 | ENSMUSP00000029987 | ENSMUSP00000006094 | Fructose-bisphosphate aldolase B. | Cytochrome P450 2D26; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.834 |
Aldob | Cyp3a11 | ENSMUSP00000029987 | ENSMUSP00000037665 | Fructose-bisphosphate aldolase B. | Cytochrome P450 3A11; Catalyzes erythromycin N-demethylation, nifedipine oxidation and testosterone 6 beta-hydroxylation; Belongs to the cytochrome P450 family. | 0.696 |
Aldob | Ugt2b5 | ENSMUSP00000029987 | ENSMUSP00000068282 | Fructose-bisphosphate aldolase B. | UDP-glucuronosyltransferase 2B17; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. | 0.427 |
Cyp2c68 | Cyp2d10 | ENSMUSP00000097071 | ENSMUSP00000072555 | Cytochrome P450, family 2, subfamily c, polypeptide 68; Belongs to the cytochrome P450 family. | Cytochrome P450 2D10; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.778 |
Cyp2c68 | Cyp2d26 | ENSMUSP00000097071 | ENSMUSP00000006094 | Cytochrome P450, family 2, subfamily c, polypeptide 68; Belongs to the cytochrome P450 family. | Cytochrome P450 2D26; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.756 |
Cyp2c68 | Cyp3a11 | ENSMUSP00000097071 | ENSMUSP00000037665 | Cytochrome P450, family 2, subfamily c, polypeptide 68; Belongs to the cytochrome P450 family. | Cytochrome P450 3A11; Catalyzes erythromycin N-demethylation, nifedipine oxidation and testosterone 6 beta-hydroxylation; Belongs to the cytochrome P450 family. | 0.824 |
Cyp2c68 | Cyp3a13 | ENSMUSP00000097071 | ENSMUSP00000031741 | Cytochrome P450, family 2, subfamily c, polypeptide 68; Belongs to the cytochrome P450 family. | Cytochrome P450 3A13; Can activate aflatoxin B1 to a genotoxic product. | 0.755 |
Cyp2c68 | Cyp3a25 | ENSMUSP00000097071 | ENSMUSP00000065585 | Cytochrome P450, family 2, subfamily c, polypeptide 68; Belongs to the cytochrome P450 family. | Cytochrome P450 3A25; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.826 |
Cyp2c68 | Cyp7a1 | ENSMUSP00000097071 | ENSMUSP00000029905 | Cytochrome P450, family 2, subfamily c, polypeptide 68; Belongs to the cytochrome P450 family. | Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of [...] | 0.791 |
Cyp2c68 | Hsd3b3 | ENSMUSP00000097071 | ENSMUSP00000102633 | Cytochrome P450, family 2, subfamily c, polypeptide 68; Belongs to the cytochrome P450 family. | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. | 0.744 |
Cyp2c68 | Hsd3b5 | ENSMUSP00000097071 | ENSMUSP00000041442 | Cytochrome P450, family 2, subfamily c, polypeptide 68; Belongs to the cytochrome P450 family. | NADPH-dependent 3-keto-steroid reductase Hsd3b5; Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Does not function as an isomerase. | 0.720 |
Cyp2c68 | Ugt2b5 | ENSMUSP00000097071 | ENSMUSP00000068282 | Cytochrome P450, family 2, subfamily c, polypeptide 68; Belongs to the cytochrome P450 family. | UDP-glucuronosyltransferase 2B17; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. | 0.944 |
Cyp2d10 | Cyp2c68 | ENSMUSP00000072555 | ENSMUSP00000097071 | Cytochrome P450 2D10; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Cytochrome P450, family 2, subfamily c, polypeptide 68; Belongs to the cytochrome P450 family. | 0.778 |
Cyp2d10 | Cyp2d26 | ENSMUSP00000072555 | ENSMUSP00000006094 | Cytochrome P450 2D10; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Cytochrome P450 2D26; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.762 |
Cyp2d10 | Cyp3a11 | ENSMUSP00000072555 | ENSMUSP00000037665 | Cytochrome P450 2D10; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Cytochrome P450 3A11; Catalyzes erythromycin N-demethylation, nifedipine oxidation and testosterone 6 beta-hydroxylation; Belongs to the cytochrome P450 family. | 0.812 |
Cyp2d10 | Cyp3a13 | ENSMUSP00000072555 | ENSMUSP00000031741 | Cytochrome P450 2D10; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Cytochrome P450 3A13; Can activate aflatoxin B1 to a genotoxic product. | 0.705 |
Cyp2d10 | Cyp3a25 | ENSMUSP00000072555 | ENSMUSP00000065585 | Cytochrome P450 2D10; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Cytochrome P450 3A25; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.851 |
Cyp2d10 | Cyp7a1 | ENSMUSP00000072555 | ENSMUSP00000029905 | Cytochrome P450 2D10; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of [...] | 0.841 |
Cyp2d10 | Hsd3b3 | ENSMUSP00000072555 | ENSMUSP00000102633 | Cytochrome P450 2D10; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. | 0.731 |
Cyp2d10 | Hsd3b5 | ENSMUSP00000072555 | ENSMUSP00000041442 | Cytochrome P450 2D10; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | NADPH-dependent 3-keto-steroid reductase Hsd3b5; Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Does not function as an isomerase. | 0.754 |