node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Col17a1 | Dsg3 | ENSMUSP00000026045 | ENSMUSP00000064718 | 120 kDa linear IgA disease antigen homolog; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. | Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.725 |
Col17a1 | Krt14 | ENSMUSP00000026045 | ENSMUSP00000007272 | 120 kDa linear IgA disease antigen homolog; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. | Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. | 0.801 |
Col17a1 | Krt16 | ENSMUSP00000026045 | ENSMUSP00000007280 | 120 kDa linear IgA disease antigen homolog; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. | Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. | 0.522 |
Col17a1 | Krt17 | ENSMUSP00000026045 | ENSMUSP00000079699 | 120 kDa linear IgA disease antigen homolog; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. | Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epit [...] | 0.477 |
Col17a1 | Krt36 | ENSMUSP00000026045 | ENSMUSP00000103039 | 120 kDa linear IgA disease antigen homolog; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. | Keratin, type I cuticular Ha6; Belongs to the intermediate filament family. | 0.443 |
Col17a1 | Krt5 | ENSMUSP00000026045 | ENSMUSP00000023709 | 120 kDa linear IgA disease antigen homolog; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. | Keratin, type II cytoskeletal 5. | 0.848 |
Col17a1 | Trp63 | ENSMUSP00000026045 | ENSMUSP00000110965 | 120 kDa linear IgA disease antigen homolog; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. | Tumor protein 63; Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates transcription of the p21 promoter (By similarity). Activates RIPK4 transcription. Plays a role in the [...] | 0.562 |
Dsg3 | Col17a1 | ENSMUSP00000064718 | ENSMUSP00000026045 | Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 120 kDa linear IgA disease antigen homolog; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. | 0.725 |
Dsg3 | Flg | ENSMUSP00000064718 | ENSMUSP00000142003 | Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Filaggrin. | 0.468 |
Dsg3 | Krt14 | ENSMUSP00000064718 | ENSMUSP00000007272 | Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. | 0.730 |
Dsg3 | Krt16 | ENSMUSP00000064718 | ENSMUSP00000007280 | Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. | 0.462 |
Dsg3 | Krt36 | ENSMUSP00000064718 | ENSMUSP00000103039 | Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Keratin, type I cuticular Ha6; Belongs to the intermediate filament family. | 0.563 |
Dsg3 | Krt5 | ENSMUSP00000064718 | ENSMUSP00000023709 | Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Keratin, type II cytoskeletal 5. | 0.540 |
Dsg3 | Lor | ENSMUSP00000064718 | ENSMUSP00000052128 | Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Loricrin; Major keratinocyte cell envelope protein. | 0.531 |
Dsg3 | Pkp1 | ENSMUSP00000064718 | ENSMUSP00000027667 | Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Plakophilin-1; Seems to play a role in junctional plaques; Belongs to the beta-catenin family. | 0.936 |
Flg | Dsg3 | ENSMUSP00000142003 | ENSMUSP00000064718 | Filaggrin. | Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.468 |
Flg | Krt14 | ENSMUSP00000142003 | ENSMUSP00000007272 | Filaggrin. | Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. | 0.756 |
Flg | Krt16 | ENSMUSP00000142003 | ENSMUSP00000007280 | Filaggrin. | Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. | 0.735 |
Flg | Krt17 | ENSMUSP00000142003 | ENSMUSP00000079699 | Filaggrin. | Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epit [...] | 0.472 |
Flg | Krt36 | ENSMUSP00000142003 | ENSMUSP00000103039 | Filaggrin. | Keratin, type I cuticular Ha6; Belongs to the intermediate filament family. | 0.692 |