node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adam2 | Adam21 | ENSMUSP00000022618 | ENSMUSP00000008582 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | Disintegrin and metalloproteinase domain-containing protein 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients. | 0.852 |
Adam2 | Adam25 | ENSMUSP00000022618 | ENSMUSP00000094420 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | Disintegrin and metalloproteinase domain-containing protein 25; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. | 0.847 |
Adam2 | Adam30 | ENSMUSP00000022618 | ENSMUSP00000060505 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | A disintegrin and metallopeptidase domain 30. | 0.840 |
Adam2 | B4galt1 | ENSMUSP00000022618 | ENSMUSP00000030121 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | Processed beta-1,4-galactosyltransferase 1; The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids; Belongs to the glycosyltransferase 7 family. | 0.578 |
Adam2 | Hyal5 | ENSMUSP00000022618 | ENSMUSP00000144011 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | Hyaluronidase-5; Catalyzes the hydrolysis of hyaluronan into smaller oligosaccharide fragments. Does not appear to be essential for fertilization. | 0.618 |
Adam2 | Ovgp1 | ENSMUSP00000022618 | ENSMUSP00000000573 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | Oviduct-specific glycoprotein; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development. | 0.525 |
Adam2 | Zp1 | ENSMUSP00000022618 | ENSMUSP00000025641 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | Processed zona pellucida sperm-binding protein 1; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida. | 0.636 |
Adam2 | Zp2 | ENSMUSP00000022618 | ENSMUSP00000033207 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | Processed zona pellucida sperm-binding protein 2; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. | 0.638 |
Adam2 | Zp3 | ENSMUSP00000022618 | ENSMUSP00000005073 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation; Belongs to the ZP domain family. ZPC subfamily. | 0.734 |
Adam21 | Adam2 | ENSMUSP00000008582 | ENSMUSP00000022618 | Disintegrin and metalloproteinase domain-containing protein 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients. | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | 0.852 |
Adam21 | Adam25 | ENSMUSP00000008582 | ENSMUSP00000094420 | Disintegrin and metalloproteinase domain-containing protein 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients. | Disintegrin and metalloproteinase domain-containing protein 25; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. | 0.817 |
Adam21 | Adam30 | ENSMUSP00000008582 | ENSMUSP00000060505 | Disintegrin and metalloproteinase domain-containing protein 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients. | A disintegrin and metallopeptidase domain 30. | 0.827 |
Adam21 | B4galt1 | ENSMUSP00000008582 | ENSMUSP00000030121 | Disintegrin and metalloproteinase domain-containing protein 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients. | Processed beta-1,4-galactosyltransferase 1; The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids; Belongs to the glycosyltransferase 7 family. | 0.500 |
Adam21 | Hyal5 | ENSMUSP00000008582 | ENSMUSP00000144011 | Disintegrin and metalloproteinase domain-containing protein 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients. | Hyaluronidase-5; Catalyzes the hydrolysis of hyaluronan into smaller oligosaccharide fragments. Does not appear to be essential for fertilization. | 0.526 |
Adam21 | Ovgp1 | ENSMUSP00000008582 | ENSMUSP00000000573 | Disintegrin and metalloproteinase domain-containing protein 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients. | Oviduct-specific glycoprotein; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development. | 0.511 |
Adam21 | Tex55 | ENSMUSP00000008582 | ENSMUSP00000113120 | Disintegrin and metalloproteinase domain-containing protein 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients. | Testis-specific expressed protein 55. | 0.485 |
Adam21 | Zp1 | ENSMUSP00000008582 | ENSMUSP00000025641 | Disintegrin and metalloproteinase domain-containing protein 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients. | Processed zona pellucida sperm-binding protein 1; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida. | 0.506 |
Adam21 | Zp2 | ENSMUSP00000008582 | ENSMUSP00000033207 | Disintegrin and metalloproteinase domain-containing protein 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients. | Processed zona pellucida sperm-binding protein 2; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. | 0.506 |
Adam21 | Zp3 | ENSMUSP00000008582 | ENSMUSP00000005073 | Disintegrin and metalloproteinase domain-containing protein 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients. | Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation; Belongs to the ZP domain family. ZPC subfamily. | 0.499 |
Adam25 | Adam2 | ENSMUSP00000094420 | ENSMUSP00000022618 | Disintegrin and metalloproteinase domain-containing protein 25; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | 0.847 |