node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
6030458C11Rik | Gid4 | ENSMUSP00000055656 | ENSMUSP00000064926 | UPF0489 protein C5orf22 homolog. | Glucose-induced degradation protein 4 homolog; Substrate-recognition subunit of the CTLH E3 ubiquitin- protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Binds proteins and peptides with a Pro/N-degron consisting of an unmodified N-terminal Pro followed by a small residue, and has the highest affinity for the peptide Pro-Gly- Leu-Trp. Binds peptides with an N-terminal sequence of the type Pro- [Ala,Gly]-[Leu,Met,Gln,Ser,Tyr]-[Glu,Gly,His,Ser,Val,Trp,Tyr]. Does not bind [...] | 0.618 |
6030458C11Rik | Prss50 | ENSMUSP00000055656 | ENSMUSP00000059668 | UPF0489 protein C5orf22 homolog. | Probable threonine protease PRSS50; May be involved in proteolysis through its threonine endopeptidase activity; Belongs to the peptidase S1 family. | 0.491 |
6030458C11Rik | Zfp729a | ENSMUSP00000055656 | ENSMUSP00000012314 | UPF0489 protein C5orf22 homolog. | Zinc finger protein 729a. | 0.749 |
Gid4 | 6030458C11Rik | ENSMUSP00000064926 | ENSMUSP00000055656 | Glucose-induced degradation protein 4 homolog; Substrate-recognition subunit of the CTLH E3 ubiquitin- protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Binds proteins and peptides with a Pro/N-degron consisting of an unmodified N-terminal Pro followed by a small residue, and has the highest affinity for the peptide Pro-Gly- Leu-Trp. Binds peptides with an N-terminal sequence of the type Pro- [Ala,Gly]-[Leu,Met,Gln,Ser,Tyr]-[Glu,Gly,His,Ser,Val,Trp,Tyr]. Does not bind [...] | UPF0489 protein C5orf22 homolog. | 0.618 |
Gid4 | Zfp729a | ENSMUSP00000064926 | ENSMUSP00000012314 | Glucose-induced degradation protein 4 homolog; Substrate-recognition subunit of the CTLH E3 ubiquitin- protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Binds proteins and peptides with a Pro/N-degron consisting of an unmodified N-terminal Pro followed by a small residue, and has the highest affinity for the peptide Pro-Gly- Leu-Trp. Binds peptides with an N-terminal sequence of the type Pro- [Ala,Gly]-[Leu,Met,Gln,Ser,Tyr]-[Glu,Gly,His,Ser,Val,Trp,Tyr]. Does not bind [...] | Zinc finger protein 729a. | 0.609 |
Pde7b | Zfp729a | ENSMUSP00000132378 | ENSMUSP00000012314 | cAMP-specific 3',5'-cyclic phosphodiesterase 7B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain. | Zinc finger protein 729a. | 0.401 |
Prss50 | 6030458C11Rik | ENSMUSP00000059668 | ENSMUSP00000055656 | Probable threonine protease PRSS50; May be involved in proteolysis through its threonine endopeptidase activity; Belongs to the peptidase S1 family. | UPF0489 protein C5orf22 homolog. | 0.491 |
Prss50 | Zfp729a | ENSMUSP00000059668 | ENSMUSP00000012314 | Probable threonine protease PRSS50; May be involved in proteolysis through its threonine endopeptidase activity; Belongs to the peptidase S1 family. | Zinc finger protein 729a. | 0.552 |
Trim28 | Zfp160 | ENSMUSP00000005705 | ENSMUSP00000086191 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 160. | 0.539 |
Trim28 | Zfp595 | ENSMUSP00000005705 | ENSMUSP00000126862 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Regulator of sex-limitation candidate 23. | 0.539 |
Trim28 | Zfp729a | ENSMUSP00000005705 | ENSMUSP00000012314 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 729a. | 0.539 |
Zfp160 | Trim28 | ENSMUSP00000086191 | ENSMUSP00000005705 | Zinc finger protein 160. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.539 |
Zfp160 | Zfp729a | ENSMUSP00000086191 | ENSMUSP00000012314 | Zinc finger protein 160. | Zinc finger protein 729a. | 0.573 |
Zfp595 | Trim28 | ENSMUSP00000126862 | ENSMUSP00000005705 | Regulator of sex-limitation candidate 23. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.539 |
Zfp595 | Zfp729a | ENSMUSP00000126862 | ENSMUSP00000012314 | Regulator of sex-limitation candidate 23. | Zinc finger protein 729a. | 0.537 |
Zfp729a | 6030458C11Rik | ENSMUSP00000012314 | ENSMUSP00000055656 | Zinc finger protein 729a. | UPF0489 protein C5orf22 homolog. | 0.749 |
Zfp729a | Gid4 | ENSMUSP00000012314 | ENSMUSP00000064926 | Zinc finger protein 729a. | Glucose-induced degradation protein 4 homolog; Substrate-recognition subunit of the CTLH E3 ubiquitin- protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Binds proteins and peptides with a Pro/N-degron consisting of an unmodified N-terminal Pro followed by a small residue, and has the highest affinity for the peptide Pro-Gly- Leu-Trp. Binds peptides with an N-terminal sequence of the type Pro- [Ala,Gly]-[Leu,Met,Gln,Ser,Tyr]-[Glu,Gly,His,Ser,Val,Trp,Tyr]. Does not bind [...] | 0.609 |
Zfp729a | Pde7b | ENSMUSP00000012314 | ENSMUSP00000132378 | Zinc finger protein 729a. | cAMP-specific 3',5'-cyclic phosphodiesterase 7B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain. | 0.401 |
Zfp729a | Prss50 | ENSMUSP00000012314 | ENSMUSP00000059668 | Zinc finger protein 729a. | Probable threonine protease PRSS50; May be involved in proteolysis through its threonine endopeptidase activity; Belongs to the peptidase S1 family. | 0.552 |
Zfp729a | Trim28 | ENSMUSP00000012314 | ENSMUSP00000005705 | Zinc finger protein 729a. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.539 |