Klk12 protein (mouse) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

Klk12

Kallikrein-related-peptidase 12; Belongs to the peptidase S1 family. (247 aa)

Predicted Functional Partners:

Spink6

0.953

Serpinb12

0.472

Krt4

0.470

Spink7

0.455

Klk14

0.447

App

0.444

Crct1

0.436

Prr9

0.426

Spink5

0.418

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
App	Klk12	ENSMUSP00000005406	ENSMUSP00000103604	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G [...]	Kallikrein-related-peptidase 12; Belongs to the peptidase S1 family.	0.444
App	Klk14	ENSMUSP00000005406	ENSMUSP00000056935	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G [...]	Kallikrein-14; Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression incl [...]	0.444
Crct1	Klk12	ENSMUSP00000029521	ENSMUSP00000103604	Cysteine-rich C-terminal 1.	Kallikrein-related-peptidase 12; Belongs to the peptidase S1 family.	0.436
Crct1	Krt4	ENSMUSP00000029521	ENSMUSP00000023797	Cysteine-rich C-terminal 1.	Keratin, type II cytoskeletal 4.	0.483
Crct1	Prr9	ENSMUSP00000029521	ENSMUSP00000068470	Cysteine-rich C-terminal 1.	Proline-rich protein 9.	0.570
Klk12	App	ENSMUSP00000103604	ENSMUSP00000005406	Kallikrein-related-peptidase 12; Belongs to the peptidase S1 family.	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G [...]	0.444
Klk12	Crct1	ENSMUSP00000103604	ENSMUSP00000029521	Kallikrein-related-peptidase 12; Belongs to the peptidase S1 family.	Cysteine-rich C-terminal 1.	0.436
Klk12	Klk14	ENSMUSP00000103604	ENSMUSP00000056935	Kallikrein-related-peptidase 12; Belongs to the peptidase S1 family.	Kallikrein-14; Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression incl [...]	0.447
Klk12	Krt4	ENSMUSP00000103604	ENSMUSP00000023797	Kallikrein-related-peptidase 12; Belongs to the peptidase S1 family.	Keratin, type II cytoskeletal 4.	0.470
Klk12	Prr9	ENSMUSP00000103604	ENSMUSP00000068470	Kallikrein-related-peptidase 12; Belongs to the peptidase S1 family.	Proline-rich protein 9.	0.426
Klk12	Serpinb12	ENSMUSP00000103604	ENSMUSP00000080030	Kallikrein-related-peptidase 12; Belongs to the peptidase S1 family.	Serpin B12; Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator; Belongs to the serpin family. Ov-serpin subfamily.	0.472
Klk12	Spink5	ENSMUSP00000103604	ENSMUSP00000066214	Kallikrein-related-peptidase 12; Belongs to the peptidase S1 family.	Serine peptidase inhibitor, Kazal type 5.	0.418
Klk12	Spink6	ENSMUSP00000103604	ENSMUSP00000069247	Kallikrein-related-peptidase 12; Belongs to the peptidase S1 family.	Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK5 and human KLK2, KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit human KLK1 and KLK8.	0.953
Klk12	Spink7	ENSMUSP00000103604	ENSMUSP00000075551	Kallikrein-related-peptidase 12; Belongs to the peptidase S1 family.	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor.	0.455
Klk14	App	ENSMUSP00000056935	ENSMUSP00000005406	Kallikrein-14; Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression incl [...]	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G [...]	0.444
Klk14	Klk12	ENSMUSP00000056935	ENSMUSP00000103604	Kallikrein-14; Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression incl [...]	Kallikrein-related-peptidase 12; Belongs to the peptidase S1 family.	0.447
Klk14	Spink5	ENSMUSP00000056935	ENSMUSP00000066214	Kallikrein-14; Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression incl [...]	Serine peptidase inhibitor, Kazal type 5.	0.521
Klk14	Spink6	ENSMUSP00000056935	ENSMUSP00000069247	Kallikrein-14; Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression incl [...]	Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK5 and human KLK2, KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit human KLK1 and KLK8.	0.961
Krt4	Crct1	ENSMUSP00000023797	ENSMUSP00000029521	Keratin, type II cytoskeletal 4.	Cysteine-rich C-terminal 1.	0.483
Krt4	Klk12	ENSMUSP00000023797	ENSMUSP00000103604	Keratin, type II cytoskeletal 4.	Kallikrein-related-peptidase 12; Belongs to the peptidase S1 family.	0.470