node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Agt | Gzmg | ENSMUSP00000066488 | ENSMUSP00000015578 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | Granzyme G; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.754 |
Agt | Proc | ENSMUSP00000066488 | ENSMUSP00000157269 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | Vitamin K-dependent protein C heavy chain; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family. | 0.499 |
F7 | Gzmg | ENSMUSP00000033820 | ENSMUSP00000015578 | Coagulation factor VII; Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium (By similarity). | Granzyme G; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.467 |
F7 | Proc | ENSMUSP00000033820 | ENSMUSP00000157269 | Coagulation factor VII; Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium (By similarity). | Vitamin K-dependent protein C heavy chain; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family. | 0.860 |
F7 | Tmprss11a | ENSMUSP00000033820 | ENSMUSP00000098634 | Coagulation factor VII; Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium (By similarity). | Transmembrane protease serine 11A; Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest; Belongs to the peptidase S1 family. | 0.444 |
F7 | Tmprss11c | ENSMUSP00000033820 | ENSMUSP00000062915 | Coagulation factor VII; Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium (By similarity). | Transmembrane protease serine 11C non-catalytic chain; Serine protease which has a preference for Arg or Lys in position P1 and uncharged residues in positions P2 and P3. Shows specificity towards FGF2 in vitro. | 0.459 |
Gzmc | Gzmd | ENSMUSP00000015585 | ENSMUSP00000080742 | Granzyme C; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | Granzyme D; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.606 |
Gzmc | Gzme | ENSMUSP00000015585 | ENSMUSP00000086978 | Granzyme C; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | Granzyme E; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.586 |
Gzmc | Gzmf | ENSMUSP00000015585 | ENSMUSP00000022757 | Granzyme C; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | Granzyme F; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.604 |
Gzmc | Gzmg | ENSMUSP00000015585 | ENSMUSP00000015578 | Granzyme C; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | Granzyme G; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.586 |
Gzmd | Gzmc | ENSMUSP00000080742 | ENSMUSP00000015585 | Granzyme D; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | Granzyme C; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.606 |
Gzmd | Gzme | ENSMUSP00000080742 | ENSMUSP00000086978 | Granzyme D; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | Granzyme E; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.992 |
Gzmd | Gzmf | ENSMUSP00000080742 | ENSMUSP00000022757 | Granzyme D; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | Granzyme F; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.884 |
Gzmd | Gzmg | ENSMUSP00000080742 | ENSMUSP00000015578 | Granzyme D; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | Granzyme G; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.974 |
Gzme | Gzmc | ENSMUSP00000086978 | ENSMUSP00000015585 | Granzyme E; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | Granzyme C; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.586 |
Gzme | Gzmd | ENSMUSP00000086978 | ENSMUSP00000080742 | Granzyme E; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | Granzyme D; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.992 |
Gzme | Gzmf | ENSMUSP00000086978 | ENSMUSP00000022757 | Granzyme E; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | Granzyme F; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.673 |
Gzme | Gzmg | ENSMUSP00000086978 | ENSMUSP00000015578 | Granzyme E; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | Granzyme G; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.695 |
Gzmf | Gzmc | ENSMUSP00000022757 | ENSMUSP00000015585 | Granzyme F; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | Granzyme C; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.604 |
Gzmf | Gzmd | ENSMUSP00000022757 | ENSMUSP00000080742 | Granzyme F; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | Granzyme D; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.884 |