STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GzmgGranzyme G; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily. (248 aa)    
Predicted Functional Partners:
Gzmd
Granzyme D; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily.
  
  
0.974
Gzmf
Granzyme F; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily.
  
  
0.960
Agt
Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family.
    
  0.754
Gzme
Granzyme E; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily.
  
  
0.695
Tmprss11c
Transmembrane protease serine 11C non-catalytic chain; Serine protease which has a preference for Arg or Lys in position P1 and uncharged residues in positions P2 and P3. Shows specificity towards FGF2 in vitro.
  
 
  
0.668
Gzmc
Granzyme C; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily.
  
  
0.586
Sdr39u1
Epimerase family protein SDR39U1; Putative NADP-dependent oxidoreductase.
     
 0.469
F7
Coagulation factor VII; Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium (By similarity).
  
  
0.467
Tmprss11a
Transmembrane protease serine 11A; Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest; Belongs to the peptidase S1 family.
  
 
  
0.458
Proc
Vitamin K-dependent protein C heavy chain; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family.
  
 
  
0.455
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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