Granzyme F; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily.

Granzyme G; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily.

Granzyme E; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily.

Perforin-1; Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.

Dipeptidyl peptidase 1 exclusion domain chain; Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function; Belongs to the peptidase C1 family.

Eomesodermin homolog; Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.

C-X-C chemokine receptor type 6; Receptor for the C-X-C chemokine CXCL16.

Natural cytotoxicity triggering receptor 1; Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Killer cell lectin-like receptor subfamily E member 1; Lectin-like receptor for natural killer (NK) cells. Can either inhibit or activate NK cell cytotoxic activity, depending on its binding partner. Heterodimer formation with KLRI1 mediates NK cell inhibition whereas heterodimer formation with KLRI2 mediates NK cell activation. Plays a role in allogeneic recognition by the immune system.