node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cdc40 | Cir1 | ENSMUSP00000044305 | ENSMUSP00000049834 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Corepressor interacting with RBPJ 1; Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription (By similarity). May modulate splice site selection during alternative splicing of pre- mRNAs. | 0.574 |
Cdc40 | Dhx35 | ENSMUSP00000044305 | ENSMUSP00000029186 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | 0.758 |
Cdc40 | Fam32a | ENSMUSP00000044305 | ENSMUSP00000003123 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Protein FAM32A; May induce G2 arrest and apoptosis (By similarity). May also increase cell sensitivity to apoptotic stimuli (By similarity). In cell lines, may play a role in the inhibition of anchor-independent cell growth. | 0.935 |
Cdc40 | Nkap | ENSMUSP00000044305 | ENSMUSP00000016553 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | NF-kappa-B-activating protein; Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF- kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter (By similarity). | 0.891 |
Cdc40 | Prkrip1 | ENSMUSP00000044305 | ENSMUSP00000120659 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | PRKR-interacting protein 1; Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity. | 0.962 |
Cdc40 | Prpf38a | ENSMUSP00000044305 | ENSMUSP00000078207 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Pre-mRNA-splicing factor 38A; Involved in pre-mRNA splicing as a component of the spliceosome; Belongs to the PRP38 family. | 0.930 |
Cdc40 | Slu7 | ENSMUSP00000044305 | ENSMUSP00000020681 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Belongs to the SLU7 family. | 0.997 |
Cdc40 | Yju2 | ENSMUSP00000044305 | ENSMUSP00000084082 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Splicing factor YJU2; Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex. | 0.992 |
Cir1 | Cdc40 | ENSMUSP00000049834 | ENSMUSP00000044305 | Corepressor interacting with RBPJ 1; Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription (By similarity). May modulate splice site selection during alternative splicing of pre- mRNAs. | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | 0.574 |
Cir1 | Nkap | ENSMUSP00000049834 | ENSMUSP00000016553 | Corepressor interacting with RBPJ 1; Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription (By similarity). May modulate splice site selection during alternative splicing of pre- mRNAs. | NF-kappa-B-activating protein; Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF- kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter (By similarity). | 0.690 |
Cir1 | Slu7 | ENSMUSP00000049834 | ENSMUSP00000020681 | Corepressor interacting with RBPJ 1; Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription (By similarity). May modulate splice site selection during alternative splicing of pre- mRNAs. | Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Belongs to the SLU7 family. | 0.515 |
Cir1 | Yju2 | ENSMUSP00000049834 | ENSMUSP00000084082 | Corepressor interacting with RBPJ 1; Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription (By similarity). May modulate splice site selection during alternative splicing of pre- mRNAs. | Splicing factor YJU2; Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex. | 0.557 |
Dhx35 | Cdc40 | ENSMUSP00000029186 | ENSMUSP00000044305 | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | 0.758 |
Dhx35 | Fam32a | ENSMUSP00000029186 | ENSMUSP00000003123 | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | Protein FAM32A; May induce G2 arrest and apoptosis (By similarity). May also increase cell sensitivity to apoptotic stimuli (By similarity). In cell lines, may play a role in the inhibition of anchor-independent cell growth. | 0.628 |
Dhx35 | Nkap | ENSMUSP00000029186 | ENSMUSP00000016553 | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | NF-kappa-B-activating protein; Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF- kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter (By similarity). | 0.646 |
Dhx35 | Prkrip1 | ENSMUSP00000029186 | ENSMUSP00000120659 | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | PRKR-interacting protein 1; Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity. | 0.645 |
Dhx35 | Slu7 | ENSMUSP00000029186 | ENSMUSP00000020681 | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Belongs to the SLU7 family. | 0.854 |
Dhx35 | Yju2 | ENSMUSP00000029186 | ENSMUSP00000084082 | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | Splicing factor YJU2; Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex. | 0.648 |
Fam32a | Cdc40 | ENSMUSP00000003123 | ENSMUSP00000044305 | Protein FAM32A; May induce G2 arrest and apoptosis (By similarity). May also increase cell sensitivity to apoptotic stimuli (By similarity). In cell lines, may play a role in the inhibition of anchor-independent cell growth. | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | 0.935 |
Fam32a | Dhx35 | ENSMUSP00000003123 | ENSMUSP00000029186 | Protein FAM32A; May induce G2 arrest and apoptosis (By similarity). May also increase cell sensitivity to apoptotic stimuli (By similarity). In cell lines, may play a role in the inhibition of anchor-independent cell growth. | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | 0.628 |