STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Wfdc2WAP four-disulfide core domain protein 2; Broad range protease inhibitor. (174 aa)    
Predicted Functional Partners:
Wap
Whey acidic protein; Could be a protease inhibitor. May play an important role in mammary gland development and tissue remodeling.
    
 
 0.703
Wfdc6b
WAP four-disulfide core domain protein 6B.
    
 
 0.617
Eddm3b
Epididymal protein 3B.
      
 0.614
Muc16
Mucin 16.
   
  
 0.572
Wfdc13
WAP four-disulfide core domain protein 13; Putative acid-stable proteinase inhibitor.
      
 0.557
Wfdc3
WAP four-disulfide core domain protein 3.
    
 
 0.545
Ly6g5c
Lymphocyte antigen 6 complex locus protein G5c; May have a role in hematopoietic cell differentiation.
      
 0.538
Adgrg2
Adhesion G-protein coupled receptor G2; Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
      
 0.538
Wfdc11
Protein WFDC11.
      
 0.533
Slpi
Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the innate immune response after bacterial infection. Contributes to regulate the inflammatory and immune responses to the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. R [...]
   
 
 0.529
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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