node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Anapc7 | Cep95 | ENSMUSP00000113928 | ENSMUSP00000018516 | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). | Centrosomal protein of 95 kDa. | 0.436 |
Cep135 | Cep95 | ENSMUSP00000112602 | ENSMUSP00000018516 | Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner [...] | Centrosomal protein of 95 kDa. | 0.472 |
Cep135 | Spice1 | ENSMUSP00000112602 | ENSMUSP00000058832 | Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner [...] | Spindle and centriole-associated protein 1; Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. | 0.686 |
Cep95 | Anapc7 | ENSMUSP00000018516 | ENSMUSP00000113928 | Centrosomal protein of 95 kDa. | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). | 0.436 |
Cep95 | Cep135 | ENSMUSP00000018516 | ENSMUSP00000112602 | Centrosomal protein of 95 kDa. | Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner [...] | 0.472 |
Cep95 | Fam184a | ENSMUSP00000018516 | ENSMUSP00000020003 | Centrosomal protein of 95 kDa. | Family with sequence similarity 184, member A. | 0.514 |
Cep95 | Glyr1 | ENSMUSP00000018516 | ENSMUSP00000111510 | Centrosomal protein of 95 kDa. | Putative oxidoreductase GLYR1; Nucleosome-destabilizing factor that is recruited to genes during transcriptional activation. Facilitates Pol II transcription through nucleosomes (By similarity). Binds DNA (in vitro) (By similarity). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3). Promotes KDM1B demethylase activity (By similarity). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (By similarity). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling (By si [...] | 0.437 |
Cep95 | Hectd4 | ENSMUSP00000018516 | ENSMUSP00000048345 | Centrosomal protein of 95 kDa. | HECT domain E3 ubiquitin protein ligase 4. | 0.464 |
Cep95 | Ice2 | ENSMUSP00000018516 | ENSMUSP00000034761 | Centrosomal protein of 95 kDa. | Little elongation complex subunit 2; Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. | 0.499 |
Cep95 | Lrrc27 | ENSMUSP00000018516 | ENSMUSP00000016124 | Centrosomal protein of 95 kDa. | Leucine-rich repeat-containing protein 27. | 0.438 |
Cep95 | Rspry1 | ENSMUSP00000018516 | ENSMUSP00000057275 | Centrosomal protein of 95 kDa. | RING finger and SPRY domain-containing protein 1. | 0.512 |
Cep95 | Spice1 | ENSMUSP00000018516 | ENSMUSP00000058832 | Centrosomal protein of 95 kDa. | Spindle and centriole-associated protein 1; Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. | 0.692 |
Fam184a | Cep95 | ENSMUSP00000020003 | ENSMUSP00000018516 | Family with sequence similarity 184, member A. | Centrosomal protein of 95 kDa. | 0.514 |
Glyr1 | Cep95 | ENSMUSP00000111510 | ENSMUSP00000018516 | Putative oxidoreductase GLYR1; Nucleosome-destabilizing factor that is recruited to genes during transcriptional activation. Facilitates Pol II transcription through nucleosomes (By similarity). Binds DNA (in vitro) (By similarity). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3). Promotes KDM1B demethylase activity (By similarity). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (By similarity). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling (By si [...] | Centrosomal protein of 95 kDa. | 0.437 |
Hectd4 | Cep95 | ENSMUSP00000048345 | ENSMUSP00000018516 | HECT domain E3 ubiquitin protein ligase 4. | Centrosomal protein of 95 kDa. | 0.464 |
Ice2 | Cep95 | ENSMUSP00000034761 | ENSMUSP00000018516 | Little elongation complex subunit 2; Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. | Centrosomal protein of 95 kDa. | 0.499 |
Lrrc27 | Cep95 | ENSMUSP00000016124 | ENSMUSP00000018516 | Leucine-rich repeat-containing protein 27. | Centrosomal protein of 95 kDa. | 0.438 |
Rspry1 | Cep95 | ENSMUSP00000057275 | ENSMUSP00000018516 | RING finger and SPRY domain-containing protein 1. | Centrosomal protein of 95 kDa. | 0.512 |
Spice1 | Cep135 | ENSMUSP00000058832 | ENSMUSP00000112602 | Spindle and centriole-associated protein 1; Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. | Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner [...] | 0.686 |
Spice1 | Cep95 | ENSMUSP00000058832 | ENSMUSP00000018516 | Spindle and centriole-associated protein 1; Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. | Centrosomal protein of 95 kDa. | 0.692 |