node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cdsn | Dsg4 | ENSMUSP00000048596 | ENSMUSP00000019426 | Corneodesmosin; Important for the epidermal barrier integrity. | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | 0.679 |
Cdsn | Dsp | ENSMUSP00000048596 | ENSMUSP00000115062 | Corneodesmosin; Important for the epidermal barrier integrity. | Desmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes; Belongs to the plakin or cytolinker family. | 0.465 |
Cdsn | Eps8l3 | ENSMUSP00000048596 | ENSMUSP00000042004 | Corneodesmosin; Important for the epidermal barrier integrity. | Epidermal growth factor receptor kinase substrate 8-like protein 3. | 0.644 |
Cdsn | Jup | ENSMUSP00000048596 | ENSMUSP00000001592 | Corneodesmosin; Important for the epidermal barrier integrity. | Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] | 0.632 |
Cdsn | Lpar6 | ENSMUSP00000048596 | ENSMUSP00000042327 | Corneodesmosin; Important for the epidermal barrier integrity. | Lysophosphatidic acid receptor 6; Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture (By similarity). | 0.617 |
Cdsn | Pkp1 | ENSMUSP00000048596 | ENSMUSP00000027667 | Corneodesmosin; Important for the epidermal barrier integrity. | Plakophilin-1; Seems to play a role in junctional plaques; Belongs to the beta-catenin family. | 0.576 |
Cdsn | Snrpe | ENSMUSP00000048596 | ENSMUSP00000128400 | Corneodesmosin; Important for the epidermal barrier integrity. | Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. | 0.662 |
Dsg4 | Cdsn | ENSMUSP00000019426 | ENSMUSP00000048596 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.679 |
Dsg4 | Dsp | ENSMUSP00000019426 | ENSMUSP00000115062 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | Desmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes; Belongs to the plakin or cytolinker family. | 0.782 |
Dsg4 | Eps8l3 | ENSMUSP00000019426 | ENSMUSP00000042004 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | Epidermal growth factor receptor kinase substrate 8-like protein 3. | 0.660 |
Dsg4 | Jup | ENSMUSP00000019426 | ENSMUSP00000001592 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] | 0.762 |
Dsg4 | Lpar6 | ENSMUSP00000019426 | ENSMUSP00000042327 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | Lysophosphatidic acid receptor 6; Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture (By similarity). | 0.702 |
Dsg4 | Perp | ENSMUSP00000019426 | ENSMUSP00000019998 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | P53 apoptosis effector related to PMP-22; Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway. | 0.653 |
Dsg4 | Pkp1 | ENSMUSP00000019426 | ENSMUSP00000027667 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | Plakophilin-1; Seems to play a role in junctional plaques; Belongs to the beta-catenin family. | 0.805 |
Dsg4 | Pkp2 | ENSMUSP00000019426 | ENSMUSP00000036890 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | Plakophilin 2. | 0.700 |
Dsg4 | Pkp3 | ENSMUSP00000019426 | ENSMUSP00000101654 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | Plakophilin-3; May play a role in junctional plaques. | 0.752 |
Dsg4 | Snrpe | ENSMUSP00000019426 | ENSMUSP00000128400 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. | 0.680 |
Dsp | Cdsn | ENSMUSP00000115062 | ENSMUSP00000048596 | Desmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes; Belongs to the plakin or cytolinker family. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.465 |
Dsp | Dsg4 | ENSMUSP00000115062 | ENSMUSP00000019426 | Desmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes; Belongs to the plakin or cytolinker family. | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | 0.782 |
Dsp | Jup | ENSMUSP00000115062 | ENSMUSP00000001592 | Desmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes; Belongs to the plakin or cytolinker family. | Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] | 0.999 |