STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mtrf1lPeptide chain release factor 1-like, mitochondrial; Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG. (373 aa)    
Predicted Functional Partners:
Mrpl20
39S ribosomal protein L20, mitochondrial; Belongs to the bacterial ribosomal protein bL20 family.
 
 
 0.880
Mrpl58
Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (By similarity).
   
 
 0.852
N6amt1
Methyltransferase N6AMT1; Methyltransferase that can methylate both proteins and DNA, and to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5- methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. Also acts as a N(6)-adenine- specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (By similarity). N(6)- methyladenosine (m6A) DNA is significantly [...]
  
 
 0.798
Mrrf
Ribosome-recycling factor, mitochondrial; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity); Belongs to the RRF family.
  
 
 0.796
Mrpl47
39S ribosomal protein L47, mitochondrial; Belongs to the universal ribosomal protein uL29 family.
   
 
 0.793
Mrpl49
39S ribosomal protein L49, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL49 family.
   
 
 0.787
Hemk1
MTRF1L release factor glutamine methyltransferase; N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondrial translation release factor MTRF1L.
  
 
 0.784
Gfm2
Ribosome-releasing factor 2, mitochondrial; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
  
 
 0.784
Mrps7
28S ribosomal protein S7, mitochondrial; Belongs to the universal ribosomal protein uS7 family.
  
 
 0.775
Mrps12
28S ribosomal protein S12, mitochondrial; Belongs to the universal ribosomal protein uS12 family.
  
 
 0.772
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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