node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gch1 | Pah | ENSMUSP00000087405 | ENSMUSP00000020241 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. | Phenylalanine-4-hydroxylase; Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. | 0.722 |
Gch1 | Pcbd1 | ENSMUSP00000087405 | ENSMUSP00000020298 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. | Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity); Belongs to the pterin-4-alpha-carbinolamine dehydratase family. | 0.635 |
Gch1 | Pcbd2 | ENSMUSP00000087405 | ENSMUSP00000021958 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. | Pterin-4-alpha-carbinolamine dehydratase 2; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity); Belongs to the pterin-4-alpha-carbinolamine dehydratase family. | 0.518 |
Gch1 | Qdpr | ENSMUSP00000087405 | ENSMUSP00000015950 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. | Dihydropteridine reductase; The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.763 |
Gch1 | Th | ENSMUSP00000087405 | ENSMUSP00000000219 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. | Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons. | 0.832 |
Gch1 | Tph1 | ENSMUSP00000087405 | ENSMUSP00000037752 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. | Tryptophan 5-hydroxylase 1; Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. | 0.522 |
Gch1 | Tph2 | ENSMUSP00000087405 | ENSMUSP00000006949 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. | Tryptophan 5-hydroxylase 2; Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. | 0.510 |
Hgd | Pah | ENSMUSP00000125492 | ENSMUSP00000020241 | Homogentisate 1,2-dioxygenase. | Phenylalanine-4-hydroxylase; Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. | 0.920 |
Hgd | Pcbd1 | ENSMUSP00000125492 | ENSMUSP00000020298 | Homogentisate 1,2-dioxygenase. | Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity); Belongs to the pterin-4-alpha-carbinolamine dehydratase family. | 0.703 |
Hgd | Pcbd2 | ENSMUSP00000125492 | ENSMUSP00000021958 | Homogentisate 1,2-dioxygenase. | Pterin-4-alpha-carbinolamine dehydratase 2; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity); Belongs to the pterin-4-alpha-carbinolamine dehydratase family. | 0.674 |
Hgd | Th | ENSMUSP00000125492 | ENSMUSP00000000219 | Homogentisate 1,2-dioxygenase. | Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons. | 0.707 |
Hgd | Tph1 | ENSMUSP00000125492 | ENSMUSP00000037752 | Homogentisate 1,2-dioxygenase. | Tryptophan 5-hydroxylase 1; Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. | 0.695 |
Hgd | Tph2 | ENSMUSP00000125492 | ENSMUSP00000006949 | Homogentisate 1,2-dioxygenase. | Tryptophan 5-hydroxylase 2; Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. | 0.706 |
Hnf1a | Hnf1b | ENSMUSP00000031535 | ENSMUSP00000021016 | Hepatocyte nuclear factor 1-alpha; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Binds to the inverted palindrome 5'- GTTAATNATTAAC-3'. Activates the transcription of CYP1A2, CYP2E1 and CYP3A11. Belongs to the HNF1 homeobox family. | Hepatocyte nuclear factor 1-beta; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'; Belongs to the HNF1 homeobox family. | 0.590 |
Hnf1a | Pah | ENSMUSP00000031535 | ENSMUSP00000020241 | Hepatocyte nuclear factor 1-alpha; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Binds to the inverted palindrome 5'- GTTAATNATTAAC-3'. Activates the transcription of CYP1A2, CYP2E1 and CYP3A11. Belongs to the HNF1 homeobox family. | Phenylalanine-4-hydroxylase; Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. | 0.468 |
Hnf1a | Pcbd1 | ENSMUSP00000031535 | ENSMUSP00000020298 | Hepatocyte nuclear factor 1-alpha; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Binds to the inverted palindrome 5'- GTTAATNATTAAC-3'. Activates the transcription of CYP1A2, CYP2E1 and CYP3A11. Belongs to the HNF1 homeobox family. | Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity); Belongs to the pterin-4-alpha-carbinolamine dehydratase family. | 0.967 |
Hnf1a | Pcbd2 | ENSMUSP00000031535 | ENSMUSP00000021958 | Hepatocyte nuclear factor 1-alpha; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Binds to the inverted palindrome 5'- GTTAATNATTAAC-3'. Activates the transcription of CYP1A2, CYP2E1 and CYP3A11. Belongs to the HNF1 homeobox family. | Pterin-4-alpha-carbinolamine dehydratase 2; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity); Belongs to the pterin-4-alpha-carbinolamine dehydratase family. | 0.772 |
Hnf1b | Hnf1a | ENSMUSP00000021016 | ENSMUSP00000031535 | Hepatocyte nuclear factor 1-beta; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'; Belongs to the HNF1 homeobox family. | Hepatocyte nuclear factor 1-alpha; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Binds to the inverted palindrome 5'- GTTAATNATTAAC-3'. Activates the transcription of CYP1A2, CYP2E1 and CYP3A11. Belongs to the HNF1 homeobox family. | 0.590 |
Hnf1b | Pcbd1 | ENSMUSP00000021016 | ENSMUSP00000020298 | Hepatocyte nuclear factor 1-beta; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'; Belongs to the HNF1 homeobox family. | Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity); Belongs to the pterin-4-alpha-carbinolamine dehydratase family. | 0.905 |
Hnf1b | Pcbd2 | ENSMUSP00000021016 | ENSMUSP00000021958 | Hepatocyte nuclear factor 1-beta; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'; Belongs to the HNF1 homeobox family. | Pterin-4-alpha-carbinolamine dehydratase 2; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity); Belongs to the pterin-4-alpha-carbinolamine dehydratase family. | 0.543 |