node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aldh1l2 | Amt | ENSMUSP00000020497 | ENSMUSP00000035230 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.937 |
Aldh1l2 | Dhfr | ENSMUSP00000020497 | ENSMUSP00000022218 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA. | 0.962 |
Aldh1l2 | Ftcd | ENSMUSP00000020497 | ENSMUSP00000001183 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity); In the N-terminal section; belongs to the formiminotransferase family. | 0.924 |
Aldh1l2 | Gart | ENSMUSP00000020497 | ENSMUSP00000023684 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Trifunctional purine biosynthetic protein adenosine-3; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | 0.956 |
Aldh1l2 | Mthfd1 | ENSMUSP00000020497 | ENSMUSP00000021443 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. | 0.971 |
Aldh1l2 | Mthfd2 | ENSMUSP00000020497 | ENSMUSP00000005810 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. | 0.974 |
Aldh1l2 | Mthfd2l | ENSMUSP00000020497 | ENSMUSP00000071578 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2. | 0.960 |
Aldh1l2 | Mtr | ENSMUSP00000020497 | ENSMUSP00000097442 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.941 |
Aldh1l2 | Shmt1 | ENSMUSP00000020497 | ENSMUSP00000018744 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. | 0.955 |
Aldh1l2 | Shmt2 | ENSMUSP00000020497 | ENSMUSP00000026470 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (By similarity). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (By similarity). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (By s [...] | 0.968 |
Amt | Aldh1l2 | ENSMUSP00000035230 | ENSMUSP00000020497 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | 0.937 |
Amt | Dhfr | ENSMUSP00000035230 | ENSMUSP00000022218 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA. | 0.938 |
Amt | Ftcd | ENSMUSP00000035230 | ENSMUSP00000001183 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity); In the N-terminal section; belongs to the formiminotransferase family. | 0.942 |
Amt | Gart | ENSMUSP00000035230 | ENSMUSP00000023684 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Trifunctional purine biosynthetic protein adenosine-3; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | 0.965 |
Amt | Mthfd1 | ENSMUSP00000035230 | ENSMUSP00000021443 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. | 0.963 |
Amt | Mthfd2 | ENSMUSP00000035230 | ENSMUSP00000005810 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. | 0.981 |
Amt | Mthfd2l | ENSMUSP00000035230 | ENSMUSP00000071578 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2. | 0.982 |
Amt | Mtr | ENSMUSP00000035230 | ENSMUSP00000097442 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.940 |
Amt | Shmt1 | ENSMUSP00000035230 | ENSMUSP00000018744 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. | 0.977 |
Amt | Shmt2 | ENSMUSP00000035230 | ENSMUSP00000026470 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (By similarity). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (By similarity). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (By s [...] | 0.978 |