node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Crebbp | Hba-x | ENSMUSP00000023165 | ENSMUSP00000020531 | Histone lysine acetyltransferase CREBBP; Acetylates histones, giving a specific tag for transcriptional activation (By similarity). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes (By similarity). Acts as a coactivator of ALX1 (By similarity). Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK- ARNTL/BMAL1 heterodimers (By simila [...] | Hemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin; Belongs to the globin family. | 0.844 |
Crebbp | Jun | ENSMUSP00000023165 | ENSMUSP00000102711 | Histone lysine acetyltransferase CREBBP; Acetylates histones, giving a specific tag for transcriptional activation (By similarity). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes (By similarity). Acts as a coactivator of ALX1 (By similarity). Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK- ARNTL/BMAL1 heterodimers (By simila [...] | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 (By similarity). Binds to the USP28 promoter (By similarity). | 0.997 |
Crebbp | Jund | ENSMUSP00000023165 | ENSMUSP00000092901 | Histone lysine acetyltransferase CREBBP; Acetylates histones, giving a specific tag for transcriptional activation (By similarity). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes (By similarity). Acts as a coactivator of ALX1 (By similarity). Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK- ARNTL/BMAL1 heterodimers (By simila [...] | Transcription factor jun-D; Transcription factor binding AP-1 sites. | 0.702 |
Crebbp | Smad2 | ENSMUSP00000023165 | ENSMUSP00000130115 | Histone lysine acetyltransferase CREBBP; Acetylates histones, giving a specific tag for transcriptional activation (By similarity). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes (By similarity). Acts as a coactivator of ALX1 (By similarity). Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK- ARNTL/BMAL1 heterodimers (By simila [...] | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | 0.993 |
Hba-x | Crebbp | ENSMUSP00000020531 | ENSMUSP00000023165 | Hemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin; Belongs to the globin family. | Histone lysine acetyltransferase CREBBP; Acetylates histones, giving a specific tag for transcriptional activation (By similarity). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes (By similarity). Acts as a coactivator of ALX1 (By similarity). Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK- ARNTL/BMAL1 heterodimers (By simila [...] | 0.844 |
Hba-x | Hbb-bh1 | ENSMUSP00000020531 | ENSMUSP00000064865 | Hemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin; Belongs to the globin family. | Hemoglobin subunit beta-H1; This is an embryonic beta-type chain. | 0.992 |
Hba-x | Hbb-bh2 | ENSMUSP00000020531 | ENSMUSP00000102479 | Hemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin; Belongs to the globin family. | Predicted gene, EG436003; Belongs to the globin family. | 0.899 |
Hba-x | Hbb-bs | ENSMUSP00000020531 | ENSMUSP00000023934 | Hemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin; Belongs to the globin family. | Hemoglobin subunit beta-1; Involved in oxygen transport from the lung to the various peripheral tissues. | 0.904 |
Hba-x | Hbb-bt | ENSMUSP00000020531 | ENSMUSP00000095794 | Hemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin; Belongs to the globin family. | Hemoglobin, beta adult t chain. | 0.903 |
Hba-x | Hbb-y | ENSMUSP00000020531 | ENSMUSP00000033229 | Hemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin; Belongs to the globin family. | Hemoglobin subunit epsilon-Y2; Hemoglobin epsilon chain is a beta-type chain found in early embryos; Belongs to the globin family. | 0.988 |
Hba-x | Hp | ENSMUSP00000020531 | ENSMUSP00000074436 | Hemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin; Belongs to the globin family. | Haptoglobin alpha chain; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pat [...] | 0.849 |
Hba-x | Jun | ENSMUSP00000020531 | ENSMUSP00000102711 | Hemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin; Belongs to the globin family. | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 (By similarity). Binds to the USP28 promoter (By similarity). | 0.841 |
Hba-x | Jund | ENSMUSP00000020531 | ENSMUSP00000092901 | Hemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin; Belongs to the globin family. | Transcription factor jun-D; Transcription factor binding AP-1 sites. | 0.874 |
Hba-x | Smad2 | ENSMUSP00000020531 | ENSMUSP00000130115 | Hemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin; Belongs to the globin family. | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | 0.907 |
Hbb-bh1 | Hba-x | ENSMUSP00000064865 | ENSMUSP00000020531 | Hemoglobin subunit beta-H1; This is an embryonic beta-type chain. | Hemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin; Belongs to the globin family. | 0.992 |
Hbb-bh1 | Hbb-bh2 | ENSMUSP00000064865 | ENSMUSP00000102479 | Hemoglobin subunit beta-H1; This is an embryonic beta-type chain. | Predicted gene, EG436003; Belongs to the globin family. | 0.777 |
Hbb-bh1 | Hbb-bs | ENSMUSP00000064865 | ENSMUSP00000023934 | Hemoglobin subunit beta-H1; This is an embryonic beta-type chain. | Hemoglobin subunit beta-1; Involved in oxygen transport from the lung to the various peripheral tissues. | 0.762 |
Hbb-bh1 | Hbb-bt | ENSMUSP00000064865 | ENSMUSP00000095794 | Hemoglobin subunit beta-H1; This is an embryonic beta-type chain. | Hemoglobin, beta adult t chain. | 0.766 |
Hbb-bh1 | Hbb-y | ENSMUSP00000064865 | ENSMUSP00000033229 | Hemoglobin subunit beta-H1; This is an embryonic beta-type chain. | Hemoglobin subunit epsilon-Y2; Hemoglobin epsilon chain is a beta-type chain found in early embryos; Belongs to the globin family. | 0.955 |
Hbb-bh1 | Hp | ENSMUSP00000064865 | ENSMUSP00000074436 | Hemoglobin subunit beta-H1; This is an embryonic beta-type chain. | Haptoglobin alpha chain; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pat [...] | 0.619 |