node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cgrrf1 | Rnf121 | ENSMUSP00000070548 | ENSMUSP00000094396 | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | RING finger protein 121; Belongs to the RNF121 family. | 0.477 |
Cgrrf1 | Rnf130 | ENSMUSP00000070548 | ENSMUSP00000099837 | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | E3 ubiquitin-protein ligase RNF130; Acts as an E3 ubiquitin-protein ligase (By similarity). May have a role during the programmed cell death of hematopoietic cells. | 0.485 |
Cgrrf1 | Rnf145 | ENSMUSP00000070548 | ENSMUSP00000019333 | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | RING finger protein 145; E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, negatively regulates the phagocyte oxidative burst by controlling the turnover of the NADPH oxidase complex subunits. Promotes monoubiquitination of CYBA and 'Lys-48'- linked polyubiquitination and degradation of CYBB NADPH oxidase catalytic subunits, both essential for the generation of antimicrobial reactive oxygen species. Involved in the maintenance of cholesterol homeostasis. In response to hi [...] | 0.469 |
Cgrrf1 | Rnf170 | ENSMUSP00000070548 | ENSMUSP00000014022 | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. | 0.572 |
Cgrrf1 | Rnft1 | ENSMUSP00000070548 | ENSMUSP00000020827 | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | E3 ubiquitin-protein ligase RNFT1; E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. | 0.655 |
Heatr6 | Rnft1 | ENSMUSP00000001002 | ENSMUSP00000020827 | HEAT repeat-containing protein 6. | E3 ubiquitin-protein ligase RNFT1; E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. | 0.500 |
Rnf103 | Rnf145 | ENSMUSP00000066324 | ENSMUSP00000019333 | E3 ubiquitin-protein ligase RNF103; Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway. | RING finger protein 145; E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, negatively regulates the phagocyte oxidative burst by controlling the turnover of the NADPH oxidase complex subunits. Promotes monoubiquitination of CYBA and 'Lys-48'- linked polyubiquitination and degradation of CYBB NADPH oxidase catalytic subunits, both essential for the generation of antimicrobial reactive oxygen species. Involved in the maintenance of cholesterol homeostasis. In response to hi [...] | 0.487 |
Rnf103 | Rnf170 | ENSMUSP00000066324 | ENSMUSP00000014022 | E3 ubiquitin-protein ligase RNF103; Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway. | E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. | 0.582 |
Rnf103 | Rnft1 | ENSMUSP00000066324 | ENSMUSP00000020827 | E3 ubiquitin-protein ligase RNF103; Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway. | E3 ubiquitin-protein ligase RNFT1; E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. | 0.550 |
Rnf103 | Tmem129 | ENSMUSP00000066324 | ENSMUSP00000019439 | E3 ubiquitin-protein ligase RNF103; Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway. | E3 ubiquitin-protein ligase TM129; E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation. | 0.412 |
Rnf121 | Cgrrf1 | ENSMUSP00000094396 | ENSMUSP00000070548 | RING finger protein 121; Belongs to the RNF121 family. | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | 0.477 |
Rnf121 | Rnf130 | ENSMUSP00000094396 | ENSMUSP00000099837 | RING finger protein 121; Belongs to the RNF121 family. | E3 ubiquitin-protein ligase RNF130; Acts as an E3 ubiquitin-protein ligase (By similarity). May have a role during the programmed cell death of hematopoietic cells. | 0.432 |
Rnf121 | Rnf145 | ENSMUSP00000094396 | ENSMUSP00000019333 | RING finger protein 121; Belongs to the RNF121 family. | RING finger protein 145; E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, negatively regulates the phagocyte oxidative burst by controlling the turnover of the NADPH oxidase complex subunits. Promotes monoubiquitination of CYBA and 'Lys-48'- linked polyubiquitination and degradation of CYBB NADPH oxidase catalytic subunits, both essential for the generation of antimicrobial reactive oxygen species. Involved in the maintenance of cholesterol homeostasis. In response to hi [...] | 0.421 |
Rnf121 | Rnf170 | ENSMUSP00000094396 | ENSMUSP00000014022 | RING finger protein 121; Belongs to the RNF121 family. | E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. | 0.494 |
Rnf121 | Rnft1 | ENSMUSP00000094396 | ENSMUSP00000020827 | RING finger protein 121; Belongs to the RNF121 family. | E3 ubiquitin-protein ligase RNFT1; E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. | 0.500 |
Rnf130 | Cgrrf1 | ENSMUSP00000099837 | ENSMUSP00000070548 | E3 ubiquitin-protein ligase RNF130; Acts as an E3 ubiquitin-protein ligase (By similarity). May have a role during the programmed cell death of hematopoietic cells. | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | 0.485 |
Rnf130 | Rnf121 | ENSMUSP00000099837 | ENSMUSP00000094396 | E3 ubiquitin-protein ligase RNF130; Acts as an E3 ubiquitin-protein ligase (By similarity). May have a role during the programmed cell death of hematopoietic cells. | RING finger protein 121; Belongs to the RNF121 family. | 0.432 |
Rnf130 | Rnf145 | ENSMUSP00000099837 | ENSMUSP00000019333 | E3 ubiquitin-protein ligase RNF130; Acts as an E3 ubiquitin-protein ligase (By similarity). May have a role during the programmed cell death of hematopoietic cells. | RING finger protein 145; E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, negatively regulates the phagocyte oxidative burst by controlling the turnover of the NADPH oxidase complex subunits. Promotes monoubiquitination of CYBA and 'Lys-48'- linked polyubiquitination and degradation of CYBB NADPH oxidase catalytic subunits, both essential for the generation of antimicrobial reactive oxygen species. Involved in the maintenance of cholesterol homeostasis. In response to hi [...] | 0.408 |
Rnf130 | Rnf183 | ENSMUSP00000099837 | ENSMUSP00000103079 | E3 ubiquitin-protein ligase RNF130; Acts as an E3 ubiquitin-protein ligase (By similarity). May have a role during the programmed cell death of hematopoietic cells. | E3 ubiquitin-protein ligase RNF183; Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (By similarity). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (By similarity). | 0.487 |
Rnf130 | Rnf223 | ENSMUSP00000099837 | ENSMUSP00000147415 | E3 ubiquitin-protein ligase RNF130; Acts as an E3 ubiquitin-protein ligase (By similarity). May have a role during the programmed cell death of hematopoietic cells. | RING finger protein 223. | 0.597 |