node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aldh1l2 | Atic | ENSMUSP00000020497 | ENSMUSP00000027384 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | 0.511 |
Aldh1l2 | Dhfr | ENSMUSP00000020497 | ENSMUSP00000022218 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA. | 0.962 |
Aldh1l2 | Ftcd | ENSMUSP00000020497 | ENSMUSP00000001183 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity); In the N-terminal section; belongs to the formiminotransferase family. | 0.924 |
Aldh1l2 | Gart | ENSMUSP00000020497 | ENSMUSP00000023684 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Trifunctional purine biosynthetic protein adenosine-3; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | 0.956 |
Aldh1l2 | Mthfd1 | ENSMUSP00000020497 | ENSMUSP00000021443 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. | 0.971 |
Aldh1l2 | Mthfr | ENSMUSP00000020497 | ENSMUSP00000069774 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Methylenetetrahydrofolate reductase; Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. | 0.525 |
Aldh1l2 | Mtr | ENSMUSP00000020497 | ENSMUSP00000097442 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.941 |
Aldh1l2 | Shmt1 | ENSMUSP00000020497 | ENSMUSP00000018744 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. | 0.955 |
Aldh1l2 | Shmt2 | ENSMUSP00000020497 | ENSMUSP00000026470 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (By similarity). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (By similarity). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (By s [...] | 0.968 |
Atic | Aldh1l2 | ENSMUSP00000027384 | ENSMUSP00000020497 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | 0.511 |
Atic | Dhfr | ENSMUSP00000027384 | ENSMUSP00000022218 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA. | 0.981 |
Atic | Ftcd | ENSMUSP00000027384 | ENSMUSP00000001183 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity); In the N-terminal section; belongs to the formiminotransferase family. | 0.927 |
Atic | Gart | ENSMUSP00000027384 | ENSMUSP00000023684 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Trifunctional purine biosynthetic protein adenosine-3; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | 0.999 |
Atic | Mthfd1 | ENSMUSP00000027384 | ENSMUSP00000021443 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. | 0.994 |
Atic | Mthfr | ENSMUSP00000027384 | ENSMUSP00000069774 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Methylenetetrahydrofolate reductase; Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. | 0.788 |
Atic | Mtr | ENSMUSP00000027384 | ENSMUSP00000097442 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.954 |
Atic | Shmt1 | ENSMUSP00000027384 | ENSMUSP00000018744 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. | 0.994 |
Atic | Shmt2 | ENSMUSP00000027384 | ENSMUSP00000026470 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (By similarity). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (By similarity). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (By s [...] | 0.994 |
Atic | Tyms | ENSMUSP00000027384 | ENSMUSP00000026846 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. | 0.827 |
Dhfr | Aldh1l2 | ENSMUSP00000022218 | ENSMUSP00000020497 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA. | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | 0.962 |