STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Serpina1fAlpha-1-antitrypsin 1-6; Inhibitor of serine proteases. Belongs to the serpin family. (411 aa)    
Predicted Functional Partners:
Defb29
Beta-defensin 29; Has antibacterial activity.
   
  
 0.746
Ahsg
Alpha-2-HS-glycoprotein; Probably involved in differentiation; Belongs to the fetuin family.
   
  
 0.663
Defb28
Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.
   
  
 0.652
Serpinc1
Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity).
  
  
0.564
Defb42
Beta-defensin 42; Has bactericidal activity (By similarity). May play a role in the antimicrobial protection of sperm and urogenital tract epithelia ; Belongs to the beta-defensin family.
   
    0.558
Wfdc15b
WAP four-disulfide core domain protein 15B; Antibacterial protein which inhibits the growth of E.coli and S.aureus.
   
  
 0.557
Dhrs7c
Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
      
 0.549
Orm1
Alpha-1-acid glycoprotein 1; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction.
   
 
 0.534
Wfdc16
WAP four-disulfide core domain 16.
   
  
 0.520
Orm3
Alpha-1-acid glycoprotein 3; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction.
   
 
 0.517
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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