STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Slc6a18Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter in kidneys. Required CLTRN for cell surface expression and for its amino acid transporter activity. (615 aa)    
Predicted Functional Partners:
Cltrn
Collectrin; Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their activity. May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane. Regulator of SNARE complex function. Stimulator of beta cell replication.
   
 
 0.941
Ace2
Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency (By similarity). By cleavage of angiotensin II, may be an important regulator of heart function. By cleavage of angiotensin II, may also have a protective role in acute lung injury. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19, regulating its tr [...]
   
 
 0.744
Slc36a2
Proton-coupled amino acid transporter 2; Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids amino acids such as glycine, alanine and proline. Inhibited by sarcosine.
   
  
 0.710
Clptm1l
Cleft lip and palate transmembrane protein 1-like protein; Enhances cisplatin-mediated apoptosis, when overexpressed. Belongs to the CLPTM1 family.
      
 0.688
Slc12a1
Solute carrier family 12 member 1; Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system.
   
  
 0.654
Tmem174
Transmembrane protein 174.
   
  
 0.575
Slc5a2
Sodium/glucose cotransporter 2; Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
   
  
 0.554
Slc22a19
Solute carrier family 22 member 19; Sodium-independent organic anion transporter which shows high specificity for estrone sulfate, dehydroepiandrosterone sulfate, and the mycotoxin ochratoxin A (OTA). Transport of OTA is strongly inhibited by estrone sulfate and probenecid, and to a lesser extent by 2,4-dichlorophenoxyacetic acid (2,4-D) and salicylate. Transport of estrone sulfate is inhibited by various steroid sulfate conjugates including dehydroepiandrosterone sulfate, alpha-naphthyl sulfate, beta-estradiol sulfate, 4-methylumbelliferyl sulfate and p-nitrophenyl sulfate (but not mi [...]
   
  
 0.551
Slc34a1
Sodium-dependent phosphate transport protein 2A; Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx.
   
  
 0.549
Slc12a3
Solute carrier family 12 member 3; Electroneutral sodium and chloride ion cotransporter. In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption (By similarity). Receptor for the proinflammatory cytokine IL18. Contributes to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1.
   
  
 0.529
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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