node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arnt2 | Otp | ENSMUSP00000082154 | ENSMUSP00000022195 | Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE). | Homeobox protein orthopedia; Involved in the specification of hypothalamic neuroendocrine cells. Specifically required for the specification of diencephalic dopaminergic neurons of the A11 group. | 0.653 |
Arnt2 | Pou3f2 | ENSMUSP00000082154 | ENSMUSP00000136147 | Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE). | POU domain, class 3, transcription factor 2; Transcription factor that plays a key role in neuronal differentiation. Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes [...] | 0.545 |
Arnt2 | Sim1 | ENSMUSP00000082154 | ENSMUSP00000020071 | Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE). | Single-minded homolog 1; Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. | 0.958 |
Arnt2 | Sim2 | ENSMUSP00000082154 | ENSMUSP00000072043 | Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE). | Single-minded homolog 2; Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. | 0.886 |
Crh | Otp | ENSMUSP00000061185 | ENSMUSP00000022195 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile. | Homeobox protein orthopedia; Involved in the specification of hypothalamic neuroendocrine cells. Specifically required for the specification of diencephalic dopaminergic neurons of the A11 group. | 0.513 |
Crh | Oxt | ENSMUSP00000061185 | ENSMUSP00000028764 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile. | Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin. | 0.858 |
Crh | Sim1 | ENSMUSP00000061185 | ENSMUSP00000020071 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile. | Single-minded homolog 1; Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. | 0.609 |
Crh | Trh | ENSMUSP00000061185 | ENSMUSP00000006046 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile. | Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. | 0.844 |
Foxb1 | Otp | ENSMUSP00000096197 | ENSMUSP00000022195 | Forkhead box protein B1. | Homeobox protein orthopedia; Involved in the specification of hypothalamic neuroendocrine cells. Specifically required for the specification of diencephalic dopaminergic neurons of the A11 group. | 0.628 |
Foxb1 | Sim1 | ENSMUSP00000096197 | ENSMUSP00000020071 | Forkhead box protein B1. | Single-minded homolog 1; Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. | 0.506 |
Nhlh2 | Otp | ENSMUSP00000143362 | ENSMUSP00000022195 | Helix-loop-helix protein 2; May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system. | Homeobox protein orthopedia; Involved in the specification of hypothalamic neuroendocrine cells. Specifically required for the specification of diencephalic dopaminergic neurons of the A11 group. | 0.596 |
Nhlh2 | Sim1 | ENSMUSP00000143362 | ENSMUSP00000020071 | Helix-loop-helix protein 2; May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system. | Single-minded homolog 1; Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. | 0.446 |
Otp | Arnt2 | ENSMUSP00000022195 | ENSMUSP00000082154 | Homeobox protein orthopedia; Involved in the specification of hypothalamic neuroendocrine cells. Specifically required for the specification of diencephalic dopaminergic neurons of the A11 group. | Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE). | 0.653 |
Otp | Crh | ENSMUSP00000022195 | ENSMUSP00000061185 | Homeobox protein orthopedia; Involved in the specification of hypothalamic neuroendocrine cells. Specifically required for the specification of diencephalic dopaminergic neurons of the A11 group. | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile. | 0.513 |
Otp | Foxb1 | ENSMUSP00000022195 | ENSMUSP00000096197 | Homeobox protein orthopedia; Involved in the specification of hypothalamic neuroendocrine cells. Specifically required for the specification of diencephalic dopaminergic neurons of the A11 group. | Forkhead box protein B1. | 0.628 |
Otp | Nhlh2 | ENSMUSP00000022195 | ENSMUSP00000143362 | Homeobox protein orthopedia; Involved in the specification of hypothalamic neuroendocrine cells. Specifically required for the specification of diencephalic dopaminergic neurons of the A11 group. | Helix-loop-helix protein 2; May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system. | 0.596 |
Otp | Oxt | ENSMUSP00000022195 | ENSMUSP00000028764 | Homeobox protein orthopedia; Involved in the specification of hypothalamic neuroendocrine cells. Specifically required for the specification of diencephalic dopaminergic neurons of the A11 group. | Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin. | 0.548 |
Otp | Pou3f2 | ENSMUSP00000022195 | ENSMUSP00000136147 | Homeobox protein orthopedia; Involved in the specification of hypothalamic neuroendocrine cells. Specifically required for the specification of diencephalic dopaminergic neurons of the A11 group. | POU domain, class 3, transcription factor 2; Transcription factor that plays a key role in neuronal differentiation. Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes [...] | 0.590 |
Otp | Sim1 | ENSMUSP00000022195 | ENSMUSP00000020071 | Homeobox protein orthopedia; Involved in the specification of hypothalamic neuroendocrine cells. Specifically required for the specification of diencephalic dopaminergic neurons of the A11 group. | Single-minded homolog 1; Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. | 0.802 |
Otp | Sim2 | ENSMUSP00000022195 | ENSMUSP00000072043 | Homeobox protein orthopedia; Involved in the specification of hypothalamic neuroendocrine cells. Specifically required for the specification of diencephalic dopaminergic neurons of the A11 group. | Single-minded homolog 2; Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. | 0.648 |