node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
2610002M06Rik | Capn7 | ENSMUSP00000113588 | ENSMUSP00000022451 | Charged multivesicular body protein 1b-2; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require t [...] | Calpain-7; Calcium-regulated non-lysosomal thiol-protease. | 0.625 |
2610002M06Rik | Ist1 | ENSMUSP00000113588 | ENSMUSP00000034164 | Charged multivesicular body protein 1b-2; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require t [...] | IST1 homolog; ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together wi [...] | 0.924 |
Adgb | Capn7 | ENSMUSP00000045452 | ENSMUSP00000022451 | Androglobin; Belongs to the peptidase C2 family. | Calpain-7; Calcium-regulated non-lysosomal thiol-protease. | 0.499 |
Adgb | Cast | ENSMUSP00000045452 | ENSMUSP00000065275 | Androglobin; Belongs to the peptidase C2 family. | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. | 0.444 |
Adgb | Ribc1 | ENSMUSP00000045452 | ENSMUSP00000026288 | Androglobin; Belongs to the peptidase C2 family. | RIB43A-like with coiled-coils protein 1; Belongs to the RIB43A family. | 0.503 |
C1qtnf3 | Capn7 | ENSMUSP00000106152 | ENSMUSP00000022451 | Complement C1q tumor necrosis factor-related protein 3. | Calpain-7; Calcium-regulated non-lysosomal thiol-protease. | 0.514 |
Capn7 | 2610002M06Rik | ENSMUSP00000022451 | ENSMUSP00000113588 | Calpain-7; Calcium-regulated non-lysosomal thiol-protease. | Charged multivesicular body protein 1b-2; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require t [...] | 0.625 |
Capn7 | Adgb | ENSMUSP00000022451 | ENSMUSP00000045452 | Calpain-7; Calcium-regulated non-lysosomal thiol-protease. | Androglobin; Belongs to the peptidase C2 family. | 0.499 |
Capn7 | C1qtnf3 | ENSMUSP00000022451 | ENSMUSP00000106152 | Calpain-7; Calcium-regulated non-lysosomal thiol-protease. | Complement C1q tumor necrosis factor-related protein 3. | 0.514 |
Capn7 | Capns1 | ENSMUSP00000022451 | ENSMUSP00000001845 | Calpain-7; Calcium-regulated non-lysosomal thiol-protease. | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | 0.792 |
Capn7 | Capns2 | ENSMUSP00000022451 | ENSMUSP00000100553 | Calpain-7; Calcium-regulated non-lysosomal thiol-protease. | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity (By similarity). | 0.868 |
Capn7 | Cast | ENSMUSP00000022451 | ENSMUSP00000065275 | Calpain-7; Calcium-regulated non-lysosomal thiol-protease. | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. | 0.717 |
Capn7 | Ist1 | ENSMUSP00000022451 | ENSMUSP00000034164 | Calpain-7; Calcium-regulated non-lysosomal thiol-protease. | IST1 homolog; ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together wi [...] | 0.558 |
Capn7 | Oxnad1 | ENSMUSP00000022451 | ENSMUSP00000022462 | Calpain-7; Calcium-regulated non-lysosomal thiol-protease. | Oxidoreductase NAD-binding domain-containing protein 1. | 0.474 |
Capn7 | Ribc1 | ENSMUSP00000022451 | ENSMUSP00000026288 | Calpain-7; Calcium-regulated non-lysosomal thiol-protease. | RIB43A-like with coiled-coils protein 1; Belongs to the RIB43A family. | 0.469 |
Capn7 | Tfap2a | ENSMUSP00000022451 | ENSMUSP00000105822 | Calpain-7; Calcium-regulated non-lysosomal thiol-protease. | Transcription factor AP-2-alpha; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 [...] | 0.536 |
Capns1 | Capn7 | ENSMUSP00000001845 | ENSMUSP00000022451 | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | Calpain-7; Calcium-regulated non-lysosomal thiol-protease. | 0.792 |
Capns1 | Capns2 | ENSMUSP00000001845 | ENSMUSP00000100553 | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity (By similarity). | 0.553 |
Capns1 | Cast | ENSMUSP00000001845 | ENSMUSP00000065275 | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. | 0.976 |
Capns2 | Capn7 | ENSMUSP00000100553 | ENSMUSP00000022451 | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity (By similarity). | Calpain-7; Calcium-regulated non-lysosomal thiol-protease. | 0.868 |