STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TdhL-threonine 3-dehydrogenase, mitochondrial; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate, mediating L-threonine catabolism. Belongs to the NAD(P)-dependent epimerase/dehydratase family. (373 aa)    
Predicted Functional Partners:
Gcat
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.986
Tha1
L-threonine aldolase.
    
 0.962
Sdsl
Serine dehydratase-like; Has low serine dehydratase and threonine dehydratase activity; Belongs to the serine/threonine dehydratase family.
   
 
 0.935
Sds
L-serine dehydratase/L-threonine deaminase; Belongs to the serine/threonine dehydratase family.
   
 
 0.933
Fau
Ubiquitin-like protein FUBI; Belongs to the ubiquitin family.
    
 
 0.819
Gcat-2
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial.
  
  
 0.791
Ivd
Isovaleryl-CoA dehydrogenase, mitochondrial; Belongs to the acyl-CoA dehydrogenase family.
   
  
 0.634
Mrpl38
39S ribosomal protein L38, mitochondrial.
   
 
 0.622
Rps3a1
40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3.
   
 
 0.585
Acat3
Acetyl-Coenzyme A acetyltransferase 3; Belongs to the thiolase-like superfamily. Thiolase family.
   
  
 0.573
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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