Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Abcb11 | Cyp7a1 | ENSMUSP00000099771 | ENSMUSP00000029905 | Atp-binding cassette, sub-family b (mdr/tap), member 11; Bile salt export pump; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | Cytochrome p450, family 7, subfamily a, polypeptide 1; Cholesterol 7-alpha-monooxygenase; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis; Belongs to the cytochrome P450 family | 0.890 |
| Abcb11 | Cyp8b1 | ENSMUSP00000099771 | ENSMUSP00000052989 | Atp-binding cassette, sub-family b (mdr/tap), member 11; Bile salt export pump; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids | 0.883 |
| Abcb11 | Fabp6 | ENSMUSP00000099771 | ENSMUSP00000020672 | Atp-binding cassette, sub-family b (mdr/tap), member 11; Bile salt export pump; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | Gastrotropin; Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes. Stimulates gastric acid and pepsinogen secretion (By similarity); Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family | 0.667 |
| Abcb11 | Fgf15 | ENSMUSP00000099771 | ENSMUSP00000033389 | Atp-binding cassette, sub-family b (mdr/tap), member 11; Bile salt export pump; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | Fibroblast growth factor 15; Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression; Belongs to the heparin-binding growth factors family | 0.720 |
| Abcb11 | Nr0b2 | ENSMUSP00000099771 | ENSMUSP00000039175 | Atp-binding cassette, sub-family b (mdr/tap), member 11; Bile salt export pump; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | Nuclear receptor subfamily 0 group B member 2; Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1; Belongs to the nuclear hormone receptor family. NR0 subfamily | 0.863 |
| Abcb11 | Nr1h4 | ENSMUSP00000099771 | ENSMUSP00000053092 | Atp-binding cassette, sub-family b (mdr/tap), member 11; Bile salt export pump; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | Bile acid receptor; Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved in innate immune response. The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'- AGGTCA-3' i [...] | 0.857 |
| Abcb11 | Slc10a2 | ENSMUSP00000099771 | ENSMUSP00000023835 | Atp-binding cassette, sub-family b (mdr/tap), member 11; Bile salt export pump; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | Solute carrier family 10 (sodium/bile acid cotransporter), member 2; Ileal sodium/bile acid cotransporter; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (By similarity) | 0.833 |
| Abcb11 | Slc51a | ENSMUSP00000099771 | ENSMUSP00000046286 | Atp-binding cassette, sub-family b (mdr/tap), member 11; Bile salt export pump; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | Organic solute transporter subunit alpha; Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids | 0.853 |
| Abcb11 | Slc51b | ENSMUSP00000099771 | ENSMUSP00000064494 | Atp-binding cassette, sub-family b (mdr/tap), member 11; Bile salt export pump; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | Organic solute transporter subunit beta; Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities | 0.782 |
| Cyp7a1 | Abcb11 | ENSMUSP00000029905 | ENSMUSP00000099771 | Cytochrome p450, family 7, subfamily a, polypeptide 1; Cholesterol 7-alpha-monooxygenase; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis; Belongs to the cytochrome P450 family | Atp-binding cassette, sub-family b (mdr/tap), member 11; Bile salt export pump; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | 0.890 |
| Cyp7a1 | Fabp6 | ENSMUSP00000029905 | ENSMUSP00000020672 | Cytochrome p450, family 7, subfamily a, polypeptide 1; Cholesterol 7-alpha-monooxygenase; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis; Belongs to the cytochrome P450 family | Gastrotropin; Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes. Stimulates gastric acid and pepsinogen secretion (By similarity); Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family | 0.671 |
| Cyp7a1 | Fgf15 | ENSMUSP00000029905 | ENSMUSP00000033389 | Cytochrome p450, family 7, subfamily a, polypeptide 1; Cholesterol 7-alpha-monooxygenase; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis; Belongs to the cytochrome P450 family | Fibroblast growth factor 15; Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression; Belongs to the heparin-binding growth factors family | 0.849 |
| Cyp7a1 | Nr0b2 | ENSMUSP00000029905 | ENSMUSP00000039175 | Cytochrome p450, family 7, subfamily a, polypeptide 1; Cholesterol 7-alpha-monooxygenase; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis; Belongs to the cytochrome P450 family | Nuclear receptor subfamily 0 group B member 2; Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1; Belongs to the nuclear hormone receptor family. NR0 subfamily | 0.894 |
| Cyp7a1 | Nr1h4 | ENSMUSP00000029905 | ENSMUSP00000053092 | Cytochrome p450, family 7, subfamily a, polypeptide 1; Cholesterol 7-alpha-monooxygenase; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis; Belongs to the cytochrome P450 family | Bile acid receptor; Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved in innate immune response. The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'- AGGTCA-3' i [...] | 0.880 |
| Cyp7a1 | Slc10a2 | ENSMUSP00000029905 | ENSMUSP00000023835 | Cytochrome p450, family 7, subfamily a, polypeptide 1; Cholesterol 7-alpha-monooxygenase; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis; Belongs to the cytochrome P450 family | Solute carrier family 10 (sodium/bile acid cotransporter), member 2; Ileal sodium/bile acid cotransporter; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (By similarity) | 0.841 |
| Cyp7a1 | Slc51a | ENSMUSP00000029905 | ENSMUSP00000046286 | Cytochrome p450, family 7, subfamily a, polypeptide 1; Cholesterol 7-alpha-monooxygenase; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis; Belongs to the cytochrome P450 family | Organic solute transporter subunit alpha; Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids | 0.829 |
| Cyp7a1 | Slc51b | ENSMUSP00000029905 | ENSMUSP00000064494 | Cytochrome p450, family 7, subfamily a, polypeptide 1; Cholesterol 7-alpha-monooxygenase; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis; Belongs to the cytochrome P450 family | Organic solute transporter subunit beta; Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities | 0.653 |
| Cyp8b1 | Abcb11 | ENSMUSP00000052989 | ENSMUSP00000099771 | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids | Atp-binding cassette, sub-family b (mdr/tap), member 11; Bile salt export pump; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | 0.883 |
| Cyp8b1 | Fabp6 | ENSMUSP00000052989 | ENSMUSP00000020672 | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids | Gastrotropin; Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes. Stimulates gastric acid and pepsinogen secretion (By similarity); Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family | 0.599 |
| Cyp8b1 | Fgf15 | ENSMUSP00000052989 | ENSMUSP00000033389 | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids | Fibroblast growth factor 15; Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression; Belongs to the heparin-binding growth factors family | 0.810 |
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