STRINGSTRING
Tmem8 protein (mouse) - STRING interaction network
"Tmem8" - Transmembrane protein 8 (five membrane-spanning domains) in Mus musculus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tmem8Transmembrane protein 8 (five membrane-spanning domains); May be a cell surface adhesion molecule. May be involved in the maintenance of the resting T-cell state (769 aa)    
Predicted Functional Partners:
Cd300lb
CD300 antigen like family member B; Acts as an activating immune receptor in mast cells through its interaction with ITAM-bearing adapter TYROBP (255 aa)
       
      0.674
Foxred2
FAD-dependent oxidoreductase domain containing 2; Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation (By similarity) (665 aa)
     
   
  0.576
Mettl23
Methyltransferase like 23; Probable methyltransferase (253 aa)
           
  0.501
Prpsap1
Phosphoribosyl pyrophosphate synthetase-associated protein 1; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis (385 aa)
           
  0.483
Nprl3
Nitrogen permease regulator-like 3; As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC- containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (By similarity) (569 aa)
           
  0.455
Mxra7
Matrix-remodelling associated 7 (178 aa)
           
  0.449
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mice, mouse, nude mice, transgenic mice
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