node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Abhd16a | Prrc2a | ENSMUSP00000007251 | ENSMUSP00000025253 | Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes. Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (By similarity). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G). Belongs to the AB hydrolase superfamily. ABHD16 [...] | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | 0.709 |
Bag6 | Prrc2a | ENSMUSP00000025250 | ENSMUSP00000025253 | Large proline-rich protein BAG6; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endo [...] | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | 0.722 |
Prrc2a | Abhd16a | ENSMUSP00000025253 | ENSMUSP00000007251 | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes. Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (By similarity). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G). Belongs to the AB hydrolase superfamily. ABHD16 [...] | 0.709 |
Prrc2a | Bag6 | ENSMUSP00000025253 | ENSMUSP00000025250 | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | Large proline-rich protein BAG6; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endo [...] | 0.722 |
Prrc2a | Prrc2c | ENSMUSP00000025253 | ENSMUSP00000138433 | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | Protein PRRC2C. | 0.723 |
Prrc2a | Scaf1 | ENSMUSP00000025253 | ENSMUSP00000082501 | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | Splicing factor, arginine/serine-rich 19; May function in pre-mRNA splicing; Belongs to the splicing factor SR family. | 0.772 |
Prrc2a | Ubap2l | ENSMUSP00000025253 | ENSMUSP00000066138 | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | Ubiquitin-associated protein 2-like; Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs). | 0.676 |
Prrc2a | Virma | ENSMUSP00000025253 | ENSMUSP00000103943 | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | Protein virilizer homolog; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon corr [...] | 0.655 |
Prrc2a | Ythdc2 | ENSMUSP00000025253 | ENSMUSP00000048340 | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | 3'-5' RNA helicase YTHDC2; 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNA [...] | 0.682 |
Prrc2a | Ythdf1 | ENSMUSP00000025253 | ENSMUSP00000037808 | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | YTH domain-containing family protein 1; Specifically recognizes and binds N6-methyladenosine (m6A)- containing mRNAs, and promotes mRNA translation efficiency. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (By similarity). Required to facilitate learning and memory [...] | 0.696 |
Prrc2a | Ythdf2 | ENSMUSP00000025253 | ENSMUSP00000120414 | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | YTH domain-containing family protein 2; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT and ribonuclease P/MRP complexes, depending on the context. M6A- containing mRNAs containing a binding site for RIDA/HRSP12 (5'-GGUUC- 3') are preferentially degraded by endoribonucleolytic c [...] | 0.690 |
Prrc2a | Ythdf3 | ENSMUSP00000025253 | ENSMUSP00000103983 | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | YTH domain-containing family protein 3; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs and promotes RNA translation efficiency (By similarity). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (By similarity). Shares m6A- containing mRNAs targets with YTHDF1 and YTHDF2, and regulates different processes depending on the context (By similarity). Facilitates the translation of targeted mRNAs in cooperation with YTHDF1 by binding to m6A-containing mRN [...] | 0.684 |
Prrc2c | Prrc2a | ENSMUSP00000138433 | ENSMUSP00000025253 | Protein PRRC2C. | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | 0.723 |
Prrc2c | Ubap2l | ENSMUSP00000138433 | ENSMUSP00000066138 | Protein PRRC2C. | Ubiquitin-associated protein 2-like; Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs). | 0.962 |
Scaf1 | Prrc2a | ENSMUSP00000082501 | ENSMUSP00000025253 | Splicing factor, arginine/serine-rich 19; May function in pre-mRNA splicing; Belongs to the splicing factor SR family. | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | 0.772 |
Ubap2l | Prrc2a | ENSMUSP00000066138 | ENSMUSP00000025253 | Ubiquitin-associated protein 2-like; Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs). | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | 0.676 |
Ubap2l | Prrc2c | ENSMUSP00000066138 | ENSMUSP00000138433 | Ubiquitin-associated protein 2-like; Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs). | Protein PRRC2C. | 0.962 |
Virma | Prrc2a | ENSMUSP00000103943 | ENSMUSP00000025253 | Protein virilizer homolog; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon corr [...] | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | 0.655 |
Virma | Ythdc2 | ENSMUSP00000103943 | ENSMUSP00000048340 | Protein virilizer homolog; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon corr [...] | 3'-5' RNA helicase YTHDC2; 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNA [...] | 0.902 |
Virma | Ythdf1 | ENSMUSP00000103943 | ENSMUSP00000037808 | Protein virilizer homolog; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon corr [...] | YTH domain-containing family protein 1; Specifically recognizes and binds N6-methyladenosine (m6A)- containing mRNAs, and promotes mRNA translation efficiency. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (By similarity). Required to facilitate learning and memory [...] | 0.876 |