node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bysl | Fau | ENSMUSP00000024783 | ENSMUSP00000136358 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | 0.982 |
Bysl | Ltv1 | ENSMUSP00000024783 | ENSMUSP00000019950 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Protein LTV1 homolog; Belongs to the LTV1 family. | 0.999 |
Bysl | Nob1 | ENSMUSP00000024783 | ENSMUSP00000003946 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | RNA-binding protein NOB1; May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity). | 0.999 |
Bysl | Nop14 | ENSMUSP00000024783 | ENSMUSP00000038382 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Nucleolar protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). | 0.999 |
Bysl | Pno1 | ENSMUSP00000024783 | ENSMUSP00000020317 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA. Belongs to the PNO1 family. | 0.985 |
Bysl | Riok1 | ENSMUSP00000024783 | ENSMUSP00000021866 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Serine/threonine-protein kinase RIO1; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (By similarity). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its [...] | 0.904 |
Bysl | Riok2 | ENSMUSP00000024783 | ENSMUSP00000024620 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Serine/threonine-protein kinase RIO2; Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA. May regulate the timing of the metaphase- anaphase transition during mitotic progression, and its phosphorylation, may regulate this function. | 0.997 |
Bysl | Riok3 | ENSMUSP00000024783 | ENSMUSP00000025270 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7- mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of [...] | 0.818 |
Bysl | Rps3 | ENSMUSP00000024783 | ENSMUSP00000032998 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit (By similarity). Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (By similarity). Displays high binding affinity for 7,8-dihydro-8- oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (By similarity). Has also been shown to bind with similar affinity to intact and damaged DNA (By similarity). S [...] | 0.995 |
Bysl | Tsr1 | ENSMUSP00000024783 | ENSMUSP00000039027 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus. | 0.999 |
Fau | Bysl | ENSMUSP00000136358 | ENSMUSP00000024783 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | 0.982 |
Fau | Ltv1 | ENSMUSP00000136358 | ENSMUSP00000019950 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | Protein LTV1 homolog; Belongs to the LTV1 family. | 0.979 |
Fau | Nob1 | ENSMUSP00000136358 | ENSMUSP00000003946 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | RNA-binding protein NOB1; May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity). | 0.979 |
Fau | Pno1 | ENSMUSP00000136358 | ENSMUSP00000020317 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA. Belongs to the PNO1 family. | 0.979 |
Fau | Riok1 | ENSMUSP00000136358 | ENSMUSP00000021866 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | Serine/threonine-protein kinase RIO1; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (By similarity). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its [...] | 0.979 |
Fau | Riok2 | ENSMUSP00000136358 | ENSMUSP00000024620 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | Serine/threonine-protein kinase RIO2; Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA. May regulate the timing of the metaphase- anaphase transition during mitotic progression, and its phosphorylation, may regulate this function. | 0.979 |
Fau | Riok3 | ENSMUSP00000136358 | ENSMUSP00000025270 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7- mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of [...] | 0.810 |
Fau | Rps3 | ENSMUSP00000136358 | ENSMUSP00000032998 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit (By similarity). Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (By similarity). Displays high binding affinity for 7,8-dihydro-8- oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (By similarity). Has also been shown to bind with similar affinity to intact and damaged DNA (By similarity). S [...] | 0.999 |
Fau | Tsr1 | ENSMUSP00000136358 | ENSMUSP00000039027 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus. | 0.979 |
Ltv1 | Bysl | ENSMUSP00000019950 | ENSMUSP00000024783 | Protein LTV1 homolog; Belongs to the LTV1 family. | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | 0.999 |