node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |

Cyp51 | Dhcr24 | ENSMUSP00000001507 | ENSMUSP00000038063 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol | Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates | 0.979 |

Cyp51 | Ebp | ENSMUSP00000001507 | ENSMUSP00000033509 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers; Belongs to the EBP family | 0.481 |

Cyp51 | Msmo1 | ENSMUSP00000001507 | ENSMUSP00000034015 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol | Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family | 0.996 |

Cyp51 | Sc5d | ENSMUSP00000001507 | ENSMUSP00000057354 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol | Lathosterol oxidase; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol | 0.987 |

Cyp51 | Sqle | ENSMUSP00000001507 | ENSMUSP00000022977 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol | Squalene monooxygenase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway; Belongs to the squalene monooxygenase family | 0.996 |

Cyp51 | Tm7sf2 | ENSMUSP00000001507 | ENSMUSP00000025713 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol | Delta(14)-sterol reductase; Involved in the conversion of lanosterol to cholesterol | 0.992 |

Dhcr24 | Cyp51 | ENSMUSP00000038063 | ENSMUSP00000001507 | Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol | 0.979 |

Dhcr24 | Ebp | ENSMUSP00000038063 | ENSMUSP00000033509 | Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers; Belongs to the EBP family | 0.938 |

Dhcr24 | Msmo1 | ENSMUSP00000038063 | ENSMUSP00000034015 | Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates | Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family | 0.971 |

Dhcr24 | Sc5d | ENSMUSP00000038063 | ENSMUSP00000057354 | Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates | Lathosterol oxidase; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol | 0.978 |

Dhcr24 | Sqle | ENSMUSP00000038063 | ENSMUSP00000022977 | Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates | Squalene monooxygenase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway; Belongs to the squalene monooxygenase family | 0.954 |

Dhcr24 | Tm7sf2 | ENSMUSP00000038063 | ENSMUSP00000025713 | Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates | Delta(14)-sterol reductase; Involved in the conversion of lanosterol to cholesterol | 0.975 |

Ebp | Cyp51 | ENSMUSP00000033509 | ENSMUSP00000001507 | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers; Belongs to the EBP family | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol | 0.481 |

Ebp | Dhcr24 | ENSMUSP00000033509 | ENSMUSP00000038063 | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers; Belongs to the EBP family | Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates | 0.938 |

Ebp | Msmo1 | ENSMUSP00000033509 | ENSMUSP00000034015 | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers; Belongs to the EBP family | Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family | 0.588 |

Ebp | Sc5d | ENSMUSP00000033509 | ENSMUSP00000057354 | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers; Belongs to the EBP family | Lathosterol oxidase; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol | 0.963 |

Ebp | Sqle | ENSMUSP00000033509 | ENSMUSP00000022977 | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers; Belongs to the EBP family | Squalene monooxygenase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway; Belongs to the squalene monooxygenase family | 0.411 |

Ebp | Tm7sf2 | ENSMUSP00000033509 | ENSMUSP00000025713 | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers; Belongs to the EBP family | Delta(14)-sterol reductase; Involved in the conversion of lanosterol to cholesterol | 0.961 |

Gcc2 | Igf2r | ENSMUSP00000054033 | ENSMUSP00000024599 | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 (By similarity) | Cation-independent mannose-6-phosphate receptor; Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2; Belongs to the MRL1/IGF2R family | 0.919 |

Gcc2 | Rgp1 | ENSMUSP00000054033 | ENSMUSP00000103518 | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 (By similarity) | RAB6A-GEF complex partner protein 2; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors | 0.900 |