node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adipor1 | C1qtnf9 | ENSMUSP00000107856 | ENSMUSP00000025940 | Adiponectin receptor protein 1; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. | Complement C1q and tumor necrosis factor-related protein 9; Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways. | 0.518 |
Adipor1 | Calr | ENSMUSP00000107856 | ENSMUSP00000003912 | Adiponectin receptor protein 1; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity); Belongs to the calreticulin family. | 0.606 |
Adipor1 | Calr4 | ENSMUSP00000107856 | ENSMUSP00000030285 | Adiponectin receptor protein 1; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. | Calreticulin. | 0.601 |
Adipor1 | Cdh13 | ENSMUSP00000107856 | ENSMUSP00000113527 | Adiponectin receptor protein 1; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. | Cadherin-13; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. | 0.870 |
C1qtnf12 | C1qtnf9 | ENSMUSP00000024338 | ENSMUSP00000025940 | Adipolin fC1QTNF12; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue. [Adipolin gC1QTNF12]: Acts by activating the MAP kinase. Increases insulin-stimulated glucose uptake in adipocytes. | Complement C1q and tumor necrosis factor-related protein 9; Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways. | 0.641 |
C1qtnf9 | Adipor1 | ENSMUSP00000025940 | ENSMUSP00000107856 | Complement C1q and tumor necrosis factor-related protein 9; Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways. | Adiponectin receptor protein 1; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. | 0.518 |
C1qtnf9 | C1qtnf12 | ENSMUSP00000025940 | ENSMUSP00000024338 | Complement C1q and tumor necrosis factor-related protein 9; Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways. | Adipolin fC1QTNF12; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue. [Adipolin gC1QTNF12]: Acts by activating the MAP kinase. Increases insulin-stimulated glucose uptake in adipocytes. | 0.641 |
C1qtnf9 | Calr | ENSMUSP00000025940 | ENSMUSP00000003912 | Complement C1q and tumor necrosis factor-related protein 9; Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways. | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity); Belongs to the calreticulin family. | 0.473 |
C1qtnf9 | Calr4 | ENSMUSP00000025940 | ENSMUSP00000030285 | Complement C1q and tumor necrosis factor-related protein 9; Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways. | Calreticulin. | 0.483 |
C1qtnf9 | Cdh13 | ENSMUSP00000025940 | ENSMUSP00000113527 | Complement C1q and tumor necrosis factor-related protein 9; Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways. | Cadherin-13; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. | 0.428 |
C1qtnf9 | Erfe | ENSMUSP00000025940 | ENSMUSP00000084073 | Complement C1q and tumor necrosis factor-related protein 9; Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways. | Erythroferrone; Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake. | 0.515 |
C1qtnf9 | Msr1 | ENSMUSP00000025940 | ENSMUSP00000026021 | Complement C1q and tumor necrosis factor-related protein 9; Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways. | Macrophage scavenger receptor types I and II; Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). | 0.486 |
Calr | Adipor1 | ENSMUSP00000003912 | ENSMUSP00000107856 | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity); Belongs to the calreticulin family. | Adiponectin receptor protein 1; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. | 0.606 |
Calr | C1qtnf9 | ENSMUSP00000003912 | ENSMUSP00000025940 | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity); Belongs to the calreticulin family. | Complement C1q and tumor necrosis factor-related protein 9; Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways. | 0.473 |
Calr | Calr4 | ENSMUSP00000003912 | ENSMUSP00000030285 | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity); Belongs to the calreticulin family. | Calreticulin. | 0.931 |
Calr | Cdh13 | ENSMUSP00000003912 | ENSMUSP00000113527 | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity); Belongs to the calreticulin family. | Cadherin-13; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. | 0.493 |
Calr | Msr1 | ENSMUSP00000003912 | ENSMUSP00000026021 | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity); Belongs to the calreticulin family. | Macrophage scavenger receptor types I and II; Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). | 0.884 |
Calr4 | Adipor1 | ENSMUSP00000030285 | ENSMUSP00000107856 | Calreticulin. | Adiponectin receptor protein 1; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. | 0.601 |
Calr4 | C1qtnf9 | ENSMUSP00000030285 | ENSMUSP00000025940 | Calreticulin. | Complement C1q and tumor necrosis factor-related protein 9; Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways. | 0.483 |
Calr4 | Calr | ENSMUSP00000030285 | ENSMUSP00000003912 | Calreticulin. | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity); Belongs to the calreticulin family. | 0.931 |