node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
3110040N11Rik | Cs | ENSMUSP00000026092 | ENSMUSP00000005826 | UPF0235 protein C15orf40 homolog; Belongs to the UPF0235 family. | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | 0.578 |
3110040N11Rik | Csl | ENSMUSP00000026092 | ENSMUSP00000052373 | UPF0235 protein C15orf40 homolog; Belongs to the UPF0235 family. | Citrate synthase; Belongs to the citrate synthase family. | 0.580 |
3110040N11Rik | Csnk2a1 | ENSMUSP00000026092 | ENSMUSP00000096829 | UPF0235 protein C15orf40 homolog; Belongs to the UPF0235 family. | Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...] | 0.594 |
3110040N11Rik | Csnk2a2 | ENSMUSP00000026092 | ENSMUSP00000148404 | UPF0235 protein C15orf40 homolog; Belongs to the UPF0235 family. | Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...] | 0.578 |
3110040N11Rik | Drg1 | ENSMUSP00000026092 | ENSMUSP00000020741 | UPF0235 protein C15orf40 homolog; Belongs to the UPF0235 family. | Developmentally-regulated GTP-binding protein 1; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C- 3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and bundling that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these mi [...] | 0.751 |
3110040N11Rik | Drg2 | ENSMUSP00000026092 | ENSMUSP00000018568 | UPF0235 protein C15orf40 homolog; Belongs to the UPF0235 family. | Developmentally-regulated GTP-binding protein 2; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.588 |
3110040N11Rik | Grn | ENSMUSP00000026092 | ENSMUSP00000046340 | UPF0235 protein C15orf40 homolog; Belongs to the UPF0235 family. | Paragranulin; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes. Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell prolifera [...] | 0.747 |
3110040N11Rik | Pole2 | ENSMUSP00000026092 | ENSMUSP00000021359 | UPF0235 protein C15orf40 homolog; Belongs to the UPF0235 family. | DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). | 0.749 |
3110040N11Rik | Slc25a1 | ENSMUSP00000026092 | ENSMUSP00000003622 | UPF0235 protein C15orf40 homolog; Belongs to the UPF0235 family. | Tricarboxylate transport protein, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation. Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.752 |
3110040N11Rik | Slc35e3 | ENSMUSP00000026092 | ENSMUSP00000078050 | UPF0235 protein C15orf40 homolog; Belongs to the UPF0235 family. | Solute carrier family 35 member E3; Putative transporter; Belongs to the TPT transporter family. SLC35E subfamily. | 0.569 |
Cs | 3110040N11Rik | ENSMUSP00000005826 | ENSMUSP00000026092 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | UPF0235 protein C15orf40 homolog; Belongs to the UPF0235 family. | 0.578 |
Cs | Csl | ENSMUSP00000005826 | ENSMUSP00000052373 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Citrate synthase; Belongs to the citrate synthase family. | 0.906 |
Cs | Csnk2a1 | ENSMUSP00000005826 | ENSMUSP00000096829 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...] | 0.528 |
Cs | Csnk2a2 | ENSMUSP00000005826 | ENSMUSP00000148404 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...] | 0.516 |
Cs | Drg1 | ENSMUSP00000005826 | ENSMUSP00000020741 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Developmentally-regulated GTP-binding protein 1; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C- 3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and bundling that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these mi [...] | 0.586 |
Cs | Drg2 | ENSMUSP00000005826 | ENSMUSP00000018568 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Developmentally-regulated GTP-binding protein 2; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.501 |
Cs | Grn | ENSMUSP00000005826 | ENSMUSP00000046340 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Paragranulin; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes. Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell prolifera [...] | 0.596 |
Cs | Pole2 | ENSMUSP00000005826 | ENSMUSP00000021359 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). | 0.578 |
Cs | Slc25a1 | ENSMUSP00000005826 | ENSMUSP00000003622 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Tricarboxylate transport protein, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation. Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.916 |
Csl | 3110040N11Rik | ENSMUSP00000052373 | ENSMUSP00000026092 | Citrate synthase; Belongs to the citrate synthase family. | UPF0235 protein C15orf40 homolog; Belongs to the UPF0235 family. | 0.580 |