STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pramel7Preferentially expressed antigen in melanoma-like protein 7; Promotes maintenance and self-renewal of pluripotent embryonic stem cells (ESCs), downstream of LIF/STAT3. Maintains the pluripotency state of ESCs by repressing DNA methylation through the regulation of UHRF1 stability. Mediates the proteasomal degradation of UHRF1. Is required for the establishment of the blastocyst. (479 aa)    
Predicted Functional Partners:
Pramel6
Preferentially-expressed antigen in melanoma-like 6.
  
 
0.909
Pramel5
Preferentially-expressed antigen in melanoma-like 5.
  
 
0.786
Pramel1
Preferentially expressed antigen in melanoma-like protein 1; May play a role in acrosome development and also in sperm maturation and motility; Belongs to the PRAME family.
  
 
0.785
Oog2
Oogenesin-2.
  
  
0.769
Oog4
Oog4 protein.
  
 
0.767
Oog3
Oogenesin-3; Belongs to the PRAME family.
  
 
0.765
Pramef12
PRAME family member 12.
  
 
0.764
Oog1
Oogenesin-1; May act as a Ras-mediated signaling protein in early embryogenesis; Belongs to the PRAME family.
  
  
0.754
Gm3106
Predicted gene 3106.
  
 
 
0.753
Pramef20
PRAME family member 20.
  
  
 
0.752
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.