STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Prss39Inactive serine protease 39; May play an important role in the sperm/egg interaction; released during the acrosome reaction; Belongs to the peptidase S1 family. (367 aa)    
Predicted Functional Partners:
Them7
Novel Thioesterase superfamily domain and Saposin A-type domain containing protein (0610012H03Rik).
      
 0.642
Zp3r
Zona pellucida sperm-binding protein 3 receptor; Binds to ZP3 glycoprotein in egg zona pellucida. Probably involved in interactions between sperm acrosome and egg zona pellucida during and immediately following the acrosome reaction.
   
 
 0.616
Cst13
Cystatin-13; May perform a specialized role during sperm development and maturation; Belongs to the cystatin family.
   
  
 0.582
Clca3b
Chloride channel accessory 3B.
   
 
 0.563
Olfr155
Olfactory receptor.
   
 
 0.550
Tmed11
Transmembrane emp24 domain-containing protein 11; Part of a complex whose function is to bind Ca(2+) to the ER membrane and thereby regulate the retention of ER resident proteins. Belongs to the EMP24/GP25L family.
    
 
 0.542
Eme2
Probable crossover junction endonuclease EME2; Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures.
    
 
 0.542
Olfr159
Olfactory receptor.
    
 
 0.541
Trmt9b
Probable tRNA methyltransferase 9B; May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9 (By similarity); Belongs to the methyltransferase superfamily.
    
 
 0.539
1810013L24Rik
UPF0472 protein C16orf72 homolog; Belongs to the UPF0472 family.
      
 0.538
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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