node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Anxa2 | Csrp1 | ENSMUSP00000034756 | ENSMUSP00000095169 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Belongs to the annexin family. | Cysteine and glycine-rich protein 1; Could play a role in neuronal development. | 0.475 |
Anxa2 | Eno1 | ENSMUSP00000034756 | ENSMUSP00000079727 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Belongs to the annexin family. | Enolase 1, alpha non-neuron. | 0.732 |
Anxa2 | Eno1b | ENSMUSP00000034756 | ENSMUSP00000075513 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Belongs to the annexin family. | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production; Belongs to the enolase family. | 0.752 |
Anxa2 | Flna | ENSMUSP00000034756 | ENSMUSP00000109938 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Belongs to the annexin family. | Filamin-A; Actin binding protein that promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins (By similarity). Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking. Involved in ciliogenesis. Plays a role in cell-cell contacts and adhere [...] | 0.690 |
Anxa2 | S100a6 | ENSMUSP00000034756 | ENSMUSP00000001051 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Belongs to the annexin family. | Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity); Belongs to the S-100 family. | 0.942 |
Ccdc50 | Csrp1 | ENSMUSP00000097604 | ENSMUSP00000095169 | Coiled-coil domain-containing protein 50; Involved in EGFR signaling. | Cysteine and glycine-rich protein 1; Could play a role in neuronal development. | 0.476 |
Ccdc50 | Eno1 | ENSMUSP00000097604 | ENSMUSP00000079727 | Coiled-coil domain-containing protein 50; Involved in EGFR signaling. | Enolase 1, alpha non-neuron. | 0.418 |
Ccdc50 | Eno1b | ENSMUSP00000097604 | ENSMUSP00000075513 | Coiled-coil domain-containing protein 50; Involved in EGFR signaling. | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production; Belongs to the enolase family. | 0.414 |
Csrp1 | Anxa2 | ENSMUSP00000095169 | ENSMUSP00000034756 | Cysteine and glycine-rich protein 1; Could play a role in neuronal development. | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Belongs to the annexin family. | 0.475 |
Csrp1 | Ccdc50 | ENSMUSP00000095169 | ENSMUSP00000097604 | Cysteine and glycine-rich protein 1; Could play a role in neuronal development. | Coiled-coil domain-containing protein 50; Involved in EGFR signaling. | 0.476 |
Csrp1 | Eno1 | ENSMUSP00000095169 | ENSMUSP00000079727 | Cysteine and glycine-rich protein 1; Could play a role in neuronal development. | Enolase 1, alpha non-neuron. | 0.486 |
Csrp1 | Eno1b | ENSMUSP00000095169 | ENSMUSP00000075513 | Cysteine and glycine-rich protein 1; Could play a role in neuronal development. | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production; Belongs to the enolase family. | 0.489 |
Csrp1 | Flna | ENSMUSP00000095169 | ENSMUSP00000109938 | Cysteine and glycine-rich protein 1; Could play a role in neuronal development. | Filamin-A; Actin binding protein that promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins (By similarity). Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking. Involved in ciliogenesis. Plays a role in cell-cell contacts and adhere [...] | 0.550 |
Csrp1 | Mtf1 | ENSMUSP00000095169 | ENSMUSP00000030723 | Cysteine and glycine-rich protein 1; Could play a role in neuronal development. | Metal regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE). | 0.750 |
Csrp1 | Myog | ENSMUSP00000095169 | ENSMUSP00000027730 | Cysteine and glycine-rich protein 1; Could play a role in neuronal development. | Myogenin; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast dif [...] | 0.519 |
Csrp1 | S100a6 | ENSMUSP00000095169 | ENSMUSP00000001051 | Cysteine and glycine-rich protein 1; Could play a role in neuronal development. | Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity); Belongs to the S-100 family. | 0.491 |
Csrp1 | Tagln | ENSMUSP00000095169 | ENSMUSP00000034590 | Cysteine and glycine-rich protein 1; Could play a role in neuronal development. | Transgelin; Actin cross-linking/gelling protein. | 0.476 |
Csrp1 | Zyx | ENSMUSP00000095169 | ENSMUSP00000126622 | Cysteine and glycine-rich protein 1; Could play a role in neuronal development. | Zyxin; Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion- stimulated changes in gene expression (By similarity). | 0.725 |
Eno1 | Anxa2 | ENSMUSP00000079727 | ENSMUSP00000034756 | Enolase 1, alpha non-neuron. | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Belongs to the annexin family. | 0.732 |
Eno1 | Ccdc50 | ENSMUSP00000079727 | ENSMUSP00000097604 | Enolase 1, alpha non-neuron. | Coiled-coil domain-containing protein 50; Involved in EGFR signaling. | 0.418 |