node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Agbl4 | Samd8 | ENSMUSP00000095533 | ENSMUSP00000022292 | Cytosolic carboxypeptidase 6; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes polyglutamates from the carboxy-terminus of target proteins such as MYLK. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. | Sphingomyelin synthase-related protein 1; sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphatidylethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the ea [...] | 0.475 |
Agbl4 | Tcp11l1 | ENSMUSP00000095533 | ENSMUSP00000106747 | Cytosolic carboxypeptidase 6; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes polyglutamates from the carboxy-terminus of target proteins such as MYLK. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. | T-complex protein 11-like protein 1; Belongs to the TCP11 family. | 0.537 |
Ccdc73 | Cstf3 | ENSMUSP00000106743 | ENSMUSP00000028599 | Coiled-coil domain-containing protein 73. | Cleavage stimulation factor subunit 3; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. | 0.461 |
Ccdc73 | Depdc7 | ENSMUSP00000106743 | ENSMUSP00000028595 | Coiled-coil domain-containing protein 73. | DEP domain-containing protein 7. | 0.546 |
Ccdc73 | Dnajc24 | ENSMUSP00000106743 | ENSMUSP00000099615 | Coiled-coil domain-containing protein 73. | DnaJ homolog subfamily C member 24; The iron-bound form is redox-active and can function as electron carrier (By similarity). Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron- binding. Plays a role in the diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (EEF2). | 0.486 |
Ccdc73 | Eif3m | ENSMUSP00000106743 | ENSMUSP00000028592 | Coiled-coil domain-containing protein 73. | Eukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | 0.506 |
Ccdc73 | Prrg4 | ENSMUSP00000106743 | ENSMUSP00000028593 | Coiled-coil domain-containing protein 73. | Transmembrane gamma-carboxyglutamic acid protein 4; May control axon guidance across the CNS (By similarity). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (By similarity). | 0.539 |
Ccdc73 | Qser1 | ENSMUSP00000106743 | ENSMUSP00000114062 | Coiled-coil domain-containing protein 73. | Glutamine and serine-rich 1. | 0.589 |
Ccdc73 | Tcp11l1 | ENSMUSP00000106743 | ENSMUSP00000106747 | Coiled-coil domain-containing protein 73. | T-complex protein 11-like protein 1; Belongs to the TCP11 family. | 0.662 |
Commd9 | Dnajc24 | ENSMUSP00000028584 | ENSMUSP00000099615 | COMM domain-containing protein 9; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits. | DnaJ homolog subfamily C member 24; The iron-bound form is redox-active and can function as electron carrier (By similarity). Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron- binding. Plays a role in the diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (EEF2). | 0.452 |
Commd9 | Tcp11l1 | ENSMUSP00000028584 | ENSMUSP00000106747 | COMM domain-containing protein 9; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits. | T-complex protein 11-like protein 1; Belongs to the TCP11 family. | 0.561 |
Cstf3 | Ccdc73 | ENSMUSP00000028599 | ENSMUSP00000106743 | Cleavage stimulation factor subunit 3; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. | Coiled-coil domain-containing protein 73. | 0.461 |
Cstf3 | Depdc7 | ENSMUSP00000028599 | ENSMUSP00000028595 | Cleavage stimulation factor subunit 3; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. | DEP domain-containing protein 7. | 0.632 |
Cstf3 | Eif3m | ENSMUSP00000028599 | ENSMUSP00000028592 | Cleavage stimulation factor subunit 3; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. | Eukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | 0.493 |
Cstf3 | Qser1 | ENSMUSP00000028599 | ENSMUSP00000114062 | Cleavage stimulation factor subunit 3; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. | Glutamine and serine-rich 1. | 0.629 |
Cstf3 | Tcp11l1 | ENSMUSP00000028599 | ENSMUSP00000106747 | Cleavage stimulation factor subunit 3; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. | T-complex protein 11-like protein 1; Belongs to the TCP11 family. | 0.568 |
Depdc7 | Ccdc73 | ENSMUSP00000028595 | ENSMUSP00000106743 | DEP domain-containing protein 7. | Coiled-coil domain-containing protein 73. | 0.546 |
Depdc7 | Cstf3 | ENSMUSP00000028595 | ENSMUSP00000028599 | DEP domain-containing protein 7. | Cleavage stimulation factor subunit 3; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. | 0.632 |
Depdc7 | Eif3m | ENSMUSP00000028595 | ENSMUSP00000028592 | DEP domain-containing protein 7. | Eukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | 0.629 |
Depdc7 | Prrg4 | ENSMUSP00000028595 | ENSMUSP00000028593 | DEP domain-containing protein 7. | Transmembrane gamma-carboxyglutamic acid protein 4; May control axon guidance across the CNS (By similarity). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (By similarity). | 0.469 |