node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acox2 | Dsg4 | ENSMUSP00000126464 | ENSMUSP00000019426 | Peroxisomal acyl-coenzyme A oxidase 2; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids (By similarity). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (By similarity). | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | 0.495 |
Acox2 | Tgm5 | ENSMUSP00000126464 | ENSMUSP00000028721 | Peroxisomal acyl-coenzyme A oxidase 2; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids (By similarity). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (By similarity). | Protein-glutamine gamma-glutamyltransferase 5; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes (By similarity). Belongs to the transglutaminase superfamily. Transglutaminase family. | 0.497 |
Aloxe3 | Lor | ENSMUSP00000021268 | ENSMUSP00000052128 | Hydroperoxide isomerase ALOXE3; Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty [...] | Loricrin; Major keratinocyte cell envelope protein. | 0.487 |
Aloxe3 | Tgm5 | ENSMUSP00000021268 | ENSMUSP00000028721 | Hydroperoxide isomerase ALOXE3; Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty [...] | Protein-glutamine gamma-glutamyltransferase 5; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes (By similarity). Belongs to the transglutaminase superfamily. Transglutaminase family. | 0.505 |
Cdsn | Dsg4 | ENSMUSP00000048596 | ENSMUSP00000019426 | Corneodesmosin; Important for the epidermal barrier integrity. | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | 0.679 |
Cdsn | Lor | ENSMUSP00000048596 | ENSMUSP00000052128 | Corneodesmosin; Important for the epidermal barrier integrity. | Loricrin; Major keratinocyte cell envelope protein. | 0.774 |
Cdsn | Pkp1 | ENSMUSP00000048596 | ENSMUSP00000027667 | Corneodesmosin; Important for the epidermal barrier integrity. | Plakophilin-1; Seems to play a role in junctional plaques; Belongs to the beta-catenin family. | 0.576 |
Cdsn | Sprr3 | ENSMUSP00000048596 | ENSMUSP00000056287 | Corneodesmosin; Important for the epidermal barrier integrity. | Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes; Belongs to the cornifin (SPRR) family. | 0.431 |
Cdsn | Tgm5 | ENSMUSP00000048596 | ENSMUSP00000028721 | Corneodesmosin; Important for the epidermal barrier integrity. | Protein-glutamine gamma-glutamyltransferase 5; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes (By similarity). Belongs to the transglutaminase superfamily. Transglutaminase family. | 0.579 |
Dsg4 | Acox2 | ENSMUSP00000019426 | ENSMUSP00000126464 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | Peroxisomal acyl-coenzyme A oxidase 2; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids (By similarity). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (By similarity). | 0.495 |
Dsg4 | Cdsn | ENSMUSP00000019426 | ENSMUSP00000048596 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.679 |
Dsg4 | Klk8 | ENSMUSP00000019426 | ENSMUSP00000082588 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | Kallikrein-8; Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte [...] | 0.600 |
Dsg4 | Pkp1 | ENSMUSP00000019426 | ENSMUSP00000027667 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | Plakophilin-1; Seems to play a role in junctional plaques; Belongs to the beta-catenin family. | 0.805 |
Dsg4 | Tgm5 | ENSMUSP00000019426 | ENSMUSP00000028721 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | Protein-glutamine gamma-glutamyltransferase 5; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes (By similarity). Belongs to the transglutaminase superfamily. Transglutaminase family. | 0.614 |
Exph5 | Tgm5 | ENSMUSP00000062632 | ENSMUSP00000028721 | Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking. | Protein-glutamine gamma-glutamyltransferase 5; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes (By similarity). Belongs to the transglutaminase superfamily. Transglutaminase family. | 0.490 |
Grb7 | Tgm5 | ENSMUSP00000019456 | ENSMUSP00000028721 | Growth factor receptor-bound protein 7; Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration (By similarity). Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA specie [...] | Protein-glutamine gamma-glutamyltransferase 5; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes (By similarity). Belongs to the transglutaminase superfamily. Transglutaminase family. | 0.474 |
Klk8 | Dsg4 | ENSMUSP00000082588 | ENSMUSP00000019426 | Kallikrein-8; Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte [...] | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | 0.600 |
Klk8 | Tgm5 | ENSMUSP00000082588 | ENSMUSP00000028721 | Kallikrein-8; Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte [...] | Protein-glutamine gamma-glutamyltransferase 5; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes (By similarity). Belongs to the transglutaminase superfamily. Transglutaminase family. | 0.571 |
Lor | Aloxe3 | ENSMUSP00000052128 | ENSMUSP00000021268 | Loricrin; Major keratinocyte cell envelope protein. | Hydroperoxide isomerase ALOXE3; Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty [...] | 0.487 |
Lor | Cdsn | ENSMUSP00000052128 | ENSMUSP00000048596 | Loricrin; Major keratinocyte cell envelope protein. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.774 |