node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arhgap22 | Bex3 | ENSMUSP00000107587 | ENSMUSP00000136952 | Rho GTPase-activating protein 22; Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1- dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter. | Protein BEX3; May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death; Belongs to the BEX family. | 0.498 |
Arhgap22 | Cpxm1 | ENSMUSP00000107587 | ENSMUSP00000028897 | Rho GTPase-activating protein 22; Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1- dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter. | Probable carboxypeptidase X1; May be involved in cell-cell interactions. No carboxypeptidase activity was found yet. | 0.536 |
Arhgap22 | Laptm4b | ENSMUSP00000107587 | ENSMUSP00000022867 | Rho GTPase-activating protein 22; Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1- dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter. | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF- stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTO [...] | 0.449 |
Arhgap22 | Mmrn1 | ENSMUSP00000107587 | ENSMUSP00000119609 | Rho GTPase-activating protein 22; Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1- dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter. | Multimerin-1; Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein (By similarity). | 0.433 |
Arhgap22 | Nynrin | ENSMUSP00000107587 | ENSMUSP00000129557 | Rho GTPase-activating protein 22; Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1- dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter. | Protein NYNRIN. | 0.565 |
Arhgap22 | Smim24 | ENSMUSP00000107587 | ENSMUSP00000100959 | Rho GTPase-activating protein 22; Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1- dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter. | Small integral membrane protein 24. | 0.645 |
Bex3 | Arhgap22 | ENSMUSP00000136952 | ENSMUSP00000107587 | Protein BEX3; May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death; Belongs to the BEX family. | Rho GTPase-activating protein 22; Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1- dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter. | 0.498 |
Bex3 | Cpxm1 | ENSMUSP00000136952 | ENSMUSP00000028897 | Protein BEX3; May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death; Belongs to the BEX family. | Probable carboxypeptidase X1; May be involved in cell-cell interactions. No carboxypeptidase activity was found yet. | 0.550 |
Bex3 | Laptm4b | ENSMUSP00000136952 | ENSMUSP00000022867 | Protein BEX3; May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death; Belongs to the BEX family. | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF- stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTO [...] | 0.452 |
Bex3 | Nynrin | ENSMUSP00000136952 | ENSMUSP00000129557 | Protein BEX3; May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death; Belongs to the BEX family. | Protein NYNRIN. | 0.534 |
Bex3 | Smim24 | ENSMUSP00000136952 | ENSMUSP00000100959 | Protein BEX3; May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death; Belongs to the BEX family. | Small integral membrane protein 24. | 0.607 |
Cpxm1 | Arhgap22 | ENSMUSP00000028897 | ENSMUSP00000107587 | Probable carboxypeptidase X1; May be involved in cell-cell interactions. No carboxypeptidase activity was found yet. | Rho GTPase-activating protein 22; Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1- dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter. | 0.536 |
Cpxm1 | Bex3 | ENSMUSP00000028897 | ENSMUSP00000136952 | Probable carboxypeptidase X1; May be involved in cell-cell interactions. No carboxypeptidase activity was found yet. | Protein BEX3; May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death; Belongs to the BEX family. | 0.550 |
Cpxm1 | Dbt | ENSMUSP00000028897 | ENSMUSP00000000349 | Probable carboxypeptidase X1; May be involved in cell-cell interactions. No carboxypeptidase activity was found yet. | 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase); The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component. | 0.482 |
Cpxm1 | Gdap1l1 | ENSMUSP00000028897 | ENSMUSP00000105047 | Probable carboxypeptidase X1; May be involved in cell-cell interactions. No carboxypeptidase activity was found yet. | Ganglioside-induced differentiation-associated protein 1-like 1; Belongs to the GST superfamily. | 0.539 |
Cpxm1 | Laptm4b | ENSMUSP00000028897 | ENSMUSP00000022867 | Probable carboxypeptidase X1; May be involved in cell-cell interactions. No carboxypeptidase activity was found yet. | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF- stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTO [...] | 0.509 |
Cpxm1 | Mmrn1 | ENSMUSP00000028897 | ENSMUSP00000119609 | Probable carboxypeptidase X1; May be involved in cell-cell interactions. No carboxypeptidase activity was found yet. | Multimerin-1; Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein (By similarity). | 0.473 |
Cpxm1 | Nynrin | ENSMUSP00000028897 | ENSMUSP00000129557 | Probable carboxypeptidase X1; May be involved in cell-cell interactions. No carboxypeptidase activity was found yet. | Protein NYNRIN. | 0.635 |
Cpxm1 | Smim24 | ENSMUSP00000028897 | ENSMUSP00000100959 | Probable carboxypeptidase X1; May be involved in cell-cell interactions. No carboxypeptidase activity was found yet. | Small integral membrane protein 24. | 0.676 |
Cpxm1 | Tars | ENSMUSP00000028897 | ENSMUSP00000022849 | Probable carboxypeptidase X1; May be involved in cell-cell interactions. No carboxypeptidase activity was found yet. | Threonine--tRNA ligase 1, cytoplasmic; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post- transfer stage; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.482 |