node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cdk5 | Cdk5rap1 | ENSMUSP00000030814 | ENSMUSP00000105353 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neu [...] | CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity). | 0.778 |
Cdk5rap1 | Cdk5 | ENSMUSP00000105353 | ENSMUSP00000030814 | CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity). | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neu [...] | 0.778 |
Cdk5rap1 | Dus2 | ENSMUSP00000105353 | ENSMUSP00000034375 | CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity). | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily. | 0.675 |
Cdk5rap1 | Exosc3 | ENSMUSP00000105353 | ENSMUSP00000030003 | CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity). | Exosome complex component RRP40; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] | 0.956 |
Cdk5rap1 | Exosc5 | ENSMUSP00000105353 | ENSMUSP00000145948 | CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity). | Exosome complex component RRP46; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] | 0.943 |
Cdk5rap1 | Osgepl1 | ENSMUSP00000105353 | ENSMUSP00000110128 | CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity). | Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. Belongs to the KAE1 / TsaD family. | 0.674 |
Cdk5rap1 | Prpf40a | ENSMUSP00000105353 | ENSMUSP00000075655 | CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity). | Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | 0.689 |
Cdk5rap1 | Prpf40b | ENSMUSP00000105353 | ENSMUSP00000115869 | CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity). | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | 0.712 |
Cdk5rap1 | Tmco4 | ENSMUSP00000105353 | ENSMUSP00000059320 | CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity). | Transmembrane and coiled-coil domain-containing protein 4; Belongs to the TMCO4 family. | 0.714 |
Cdk5rap1 | Trit1 | ENSMUSP00000105353 | ENSMUSP00000099709 | CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity). | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). | 0.873 |
Cdk5rap1 | Trmu | ENSMUSP00000105353 | ENSMUSP00000023019 | CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity). | Mitochondrial tRNA-specific 2-thiouridylase 1; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. | 0.731 |
Dus2 | Cdk5rap1 | ENSMUSP00000034375 | ENSMUSP00000105353 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily. | CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity). | 0.675 |
Dus2 | Osgepl1 | ENSMUSP00000034375 | ENSMUSP00000110128 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily. | Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. Belongs to the KAE1 / TsaD family. | 0.450 |
Dus2 | Trit1 | ENSMUSP00000034375 | ENSMUSP00000099709 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily. | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). | 0.678 |
Dus2 | Trmu | ENSMUSP00000034375 | ENSMUSP00000023019 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily. | Mitochondrial tRNA-specific 2-thiouridylase 1; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. | 0.612 |
Exosc3 | Cdk5rap1 | ENSMUSP00000030003 | ENSMUSP00000105353 | Exosome complex component RRP40; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] | CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity). | 0.956 |
Exosc3 | Exosc5 | ENSMUSP00000030003 | ENSMUSP00000145948 | Exosome complex component RRP40; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] | Exosome complex component RRP46; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] | 0.999 |
Exosc5 | Cdk5rap1 | ENSMUSP00000145948 | ENSMUSP00000105353 | Exosome complex component RRP46; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] | CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity). | 0.943 |
Exosc5 | Exosc3 | ENSMUSP00000145948 | ENSMUSP00000030003 | Exosome complex component RRP46; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] | Exosome complex component RRP40; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] | 0.999 |
Osgepl1 | Cdk5rap1 | ENSMUSP00000110128 | ENSMUSP00000105353 | Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. Belongs to the KAE1 / TsaD family. | CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity). | 0.674 |